| PI-3K信号通路在吗啡依赖纳洛酮激发戒断反应中的作用 |
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| 引用本文： | 朱长江,曹君利,杨丽,曾因明.PI-3K信号通路在吗啡依赖纳洛酮激发戒断反应中的作用[J].江苏大学学报(医学版),2006,16(1):8-12. |
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| 作者姓名： | 朱长江 曹君利 杨丽 曾因明 |
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| 作者单位： | 1. 江苏省麻醉医学研究所,徐州医学院附属医院麻醉科,江苏,徐州,221002;江苏大学附属医院麻醉科,江苏,镇江,212001
2. 江苏省麻醉医学研究所,徐州医学院附属医院麻醉科,江苏,徐州,221002 |
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| 摘 要： | 目的：研究PI-3K信号通路在吗啡依赖纳洛酮激发戒断反应中的作用。方法：在小鼠急性和慢性吗啡依赖和戒断模型上，采用鞘内和脑室内注射PI-3K抑制剂对吗啡依赖小鼠纳洛酮催促戒断反应的影响，探讨神经元PI-3K信号通路吗啡依赖和戒断过程中的作用。结果：鞘内预先注射PI-3K信号通路抑制剂LY294002及Wortmanin能明显加重急性和慢性吗啡依赖小鼠纳洛酮激发戒断反应。脑窜内预先注射PI-3K信号通路抑制剂LY294002及Wortmanin也明显加重急性和慢性吗啡依赖小鼠纳洛酮激发戒断反应。结论：脊髓和脊髓上中枢神经元PI-3K信号通路均参与吗啡依赖的形成及戒断反应的表达。
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| 关 键 词： | 吗啡依赖 戒断反应 磷脂酰肌醇三磷酸激酶 脊髓 小鼠 |
| 文章编号： | 1671-7783（2006）01-0008-05 |
| 收稿时间： | 2005-09-19 |
| 修稿时间： | 2005-09-19 |
The Role of Phosphoinositide 3-kinase Pathway in Morphine Dependent and Naloxone-precipitated Withdrawal Response |
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| ZHU Chang-jiang,CAO Jun-li,YANG Li,ZENG Yin-ming.The Role of Phosphoinositide 3-kinase Pathway in Morphine Dependent and Naloxone-precipitated Withdrawal Response[J].Journal of Jiangsu University Medicine Edition,2006,16(1):8-12. |
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| Authors: | ZHU Chang-jiang CAO Jun-li YANG Li ZENG Yin-ming |
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| Institution: | 1. Jiangsu Institute of Anesthesiology, Department of Anesthesiology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou Jiangsu 221002; 2. Department of Anesthesiology, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001, China |
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| Abstract: | Objective: To investigate the roles of the PI3K in morphine dependent and naloxone-precipitated withdrawal response.Methods: With the acute and chronic morphine dependent mouse model,morphine withdrawal syndrome was precipitated by an injection of naloxone.DMSO or PI3K inhibitor(LY294002 or Wortmanin) was intrathecally or intracerebroventricular injected 10 min before the administration of naloxone.The jump response of mice during the first 15 min after injection of naloxone were observed.Results: Intrathecally or intracerebroventricular Phosphoinositide 3-kinase(PI3K) inhibitor(LY294002 or Wortmanin) both aggravated morphine dependent and naloxone-precipitated withdrawal response in mice.Conclusion: Both spinal and supraspinal neuronal Phosphoinositide 3-kinase(PI3K) pathway played important role in morphine dependent and naloxone-precipitated withdrawal response in mice. |
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| Keywords: | Morphine dependence Withdrawal syndrome Phosphoinositide 3-kinase Spinal cord Mice |
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