| 尼莫地平对Ca~（2＋）和某些介质致豚鼠气管平滑肌收缩的抑制作用 |
| |
| 引用本文： | 白春学,方晓惠,钮善福,吴淦桐. 尼莫地平对Ca~（2＋）和某些介质致豚鼠气管平滑肌收缩的抑制作用[J]. 中国药理学与毒理学杂志, 1995, 0(2) |
| |
| 作者姓名： | 白春学 方晓惠 钮善福 吴淦桐 |
| |
| 作者单位： | 上海医科大学中山临床医学院肺病学教研室，基础医学院药理教研室 |
| |
| 摘 要： | 尼莫地平对Ｃａ￣（２＋）和某些介质致豚鼠气管平滑肌收缩的抑制作用白春学，方晓惠，钮善福，吴淦桐（上海医科大学中山临床医学院肺病学教研室，基础医学院药理教研室，上海２０００３２）钙通道阻滞剂对支气管的扩张作用已有不少报道［１］，但尚无涉及尼莫地平（Ｎｉ...
|
| 关 键 词： | 钙通道阻滞剂；尼莫地平；氯化钙；组胺；前列腺素类；乙酰胆碱；气管；肌，平滑 |
Inhibitory effects of nimodipine on contraction of isolated tracheal strlps of guinea pig induced by Ca2 and some mediators |
| |
| BAI Chun-Xue,FANG Xiao-Hui, NIU Shan-Fu,WU Gang-Tong,. Inhibitory effects of nimodipine on contraction of isolated tracheal strlps of guinea pig induced by Ca2 and some mediators[J]. Chinese Journal of Pharmacology and Toxicology, 1995, 0(2) |
| |
| Authors: | BAI Chun-Xue FANG Xiao-Hui NIU Shan-Fu WU Gang-Tong |
| |
| Abstract: | The effects of nimodipine(Nim)against contraction of tracheal strips of gtiinea pig in-duced by Ca2+and some mediators was studied invitro. CaCl2 and histamine(His) caused significantcumulative concentration effect relationship withpD2 values of 3.58 and 5.68 After being incubatedwith Nim 0.1 -10μmol·L-1 for 20 min,the responseselicited by CaCl2 and His were depressed and pD2 val-ues were 2.81 and 6.67 respectively . Cumulative concen-tration of Nim resulted in concentration dependent re-laxing effects on contraction of tracheal strips inducedby acetylcholine 10 μmol·L-1 and prostaglandinF2α 5 mmol·L-1 with IC50 values of 0.788 and 0.81μmol·L-1.The results indicates that Nim has a signifi-cant effect on bronch0dudtion. |
| |
| Keywords: | calcium channel blockers nimodipine calcium chlorde histamine prostagl-andins:acetv1choline:trachea: muscle smooth |
| 本文献已被 CNKI 等数据库收录！ |
