| 马钱子碱聚乳酸载药纳米粒的制备和体外评价 |
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| 引用本文： | 赵继会,刘召林,许洁,于燕燕,冯年平. 马钱子碱聚乳酸载药纳米粒的制备和体外评价[J]. 中国中药杂志, 2009, 34(17): 46-48 |
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| 作者姓名： | 赵继会 刘召林 许洁 于燕燕 冯年平 |
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| 作者单位： | 上海中医药大学 药剂教研室， 上海 201203 |
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| 基金项目： | 上海市博士点基金(2006B02)；上海市教委项目(07ZZ53)；上海市教委重点学科项目(J50302) |
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| 摘 要： | 目的：制备和评价马钱子碱聚乳酸载药纳米粒(Bru-PLA-NPs)。方法：采用溶剂扩散法制备Bru-PLA-NPs，并对其进行表征和体外释药评价。结果：制得的Bru-PLA-NPs的平均粒径为95 nm，多分散指数为0.362，Zeta电位为-15.68 mV。Bru的平均载药量和包封率分别为7%，37%。体外释药试验表明，与Bru溶液相比Bru-PLA-NPs具有明显的缓释作用。结论：采用溶剂扩散法制备的Bru-PLA-NPs粒径小，载药量高，具有明显的缓释作用。
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| 关 键 词： | 马钱子碱；聚乳酸纳米粒；体外释放 |
| 收稿时间： | 2009-01-16 |
Preparation and in vitro evaluation of brucine-loaded Polylacticacid Nanoparticles |
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| ZHAO JiHui,LIU ZhaoLin,XU Jie,YU YanYan and FENG NianPing. Preparation and in vitro evaluation of brucine-loaded Polylacticacid Nanoparticles[J]. China Journal of Chinese Materia Medica, 2009, 34(17): 46-48 |
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| Authors: | ZHAO JiHui LIU ZhaoLin XU Jie YU YanYan FENG NianPing |
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| Abstract: | Objective: To prepare and evaluate Brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs). Method: The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively. Result: The mean particle size of the prepared Bru-PLA-NPs is 95 nm with polydispersity index of 0.362. The zeta potential is -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, separately. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment. Conclusion: The Bru-PLA-NPs prepared by solvent diffusion method exhibited small particle size, high Bru-loading efficiency, and obvious sustained release in vitro |
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| Keywords: | brucine PLA nanoparticles in vitro release |
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