卒中高危个体药物干预前后脑血管血流动力学综合指标的比较

目的:评价不同药物干预措施对卒中高危个体脑血管功能的影响。方法:将上海社区或郊区农村筛选出的4415例,具有至少1项卒中危险暴露因素且脑血管血流动力学指标(CVHI)积分值<75分的高危个体,随机分为脑安胶囊、阿司匹林50mg和75mg组。1年后从上述3组干预对象中随机分别抽取445例、427例和381例作为评价对象,进行CVHI复查。结果:干预1年中,3组服药率达到96%以上,以脑安胶囊组依从性最好。干预1年后,3组干预对象的收缩压和舒张压水平均有显著降低(P<0.001);CVHI积分值平均水平均有显著提高,CVHI积分值高分的比例显著增高(P<0.001),提高的幅度依次为脑安胶囊组、75mg阿司匹林组和50mg阿司匹林组,3组提高到75分以上者的比例依次为44.0%、32.5%和33.3%。结论:实施干预1年后,脑安胶囊和阿司匹林均能显著改善血压水平和CVHI积分值,脑安胶囊和阿司匹林服药依从性均好。

Comparison of Cerebrovascular Hemodynamic Synthetic Indexes Before and After Medication Intervention in High-Risk Stroke Individuals

Objective: To evaluate the effect of different medication interventions on cerebrovascular function in high-risk stroke individuals. Methods: A total of 4 415 participants were screened from the communities and suburban regions in Shanghai, China. They had at lest one risk factor exposed and the accumulated scores of cerebrovascular hemodynamic indexes (CVHI) below 75 points in the high-risk individuals. They were randomly assigned to Nao'an capsule and aspirin (50 mg and 75 mg) groups. After one year, 445, 427 and 381 participants were randomly selected as intervention candidates from the above three groups for CVHI reexamination. Results: The medicine taking rate was more than 95% in all groups during one-year intervention, and the compliance was best in the Nao'an capsule group. Both the systolic and diastolic blood pressure levels of the intervention candidates in above three groups decreased significantly (P<0.001) after one-year intervention; the average level of CVHI accumulated scores increased significantly, and the proportion of high CVHI accumulated scores increased significantly (P<0.001). The increased range was in the order of the following: the Nao'an capsule, 75 mg aspirin and 50 mg aspirin groups. The increased proportions of more than 75 points in the three groups were as follows: 44.0%, 32.5% and 33.3%. Conclusions: Both Nao'an capsule and aspirin may significantly improve the levels of blood pressure and the CVHI accumulated scores after one-year intervention, and their medication compliance is better.