头颈部非霍奇金淋巴瘤临床特征和治疗及预后因素分析

目的:探讨原发于头颈部的非霍奇金淋巴瘤(NHL)的临床特征、治疗和预后影响因素。方法:回顾性分析107例头颈部NHL患者的临床资料。结果:本研究样本的中位年龄为54岁;最常见的原发部位为扁桃体29例(27.10%),其次为鼻腔28例(26.17%);最常见的组织学类型为弥漫性大B细胞淋巴瘤46例(42.99%),其次为NK/T淋巴瘤24例(22.43%)。化疗联合应用美罗华可以有效提高生存率;IPI和组织学类型是影响预后的危险因素,且IPI是比组织学类型影响更强的危险因素。结论:原发于头颈部的NHL是一种常见的恶性疾病,其在发病年龄、原发部位、组织学类型、治疗方法和影响预后的因素存在一定特征。

Analysis on clinical characteristics, treatments and prognostic factors of head and neck non-Hodgkin's lymphoma

Objective:To study the clinical characteristics,treatments and prognoses of the primary non-Hodgkin’s lymphoma(NHL)in head and neck.Method:Clinical manifestations and clinicopathology characteristics of 107 NHL patients in head and neck were analyzed retrospectively.Result:The median age of patients with head and neck NHL was 54 years.The most commonly primary site was tonsil(29 cases,27.10%),and the secondly primary site was nasal cavity(28 cases,26.17%).The most common histologic subtype was diffuse large B cell lymphoma(46 cases,42.99%),and the secondly one was NK/T cell lymphoma(24 cases,22.43%).We found that the combination of rituximab was superior than that of chemotherapy alone.Prognosis depended on both IPI and histological subtype,and IPI was a more dangerous factor than histological subtype.Conclusion:The primary NHL is a common neoplasm in the head and neck region.Characteristic in age,primary site,histologic subtype,treatment and prognostic factors were helpful to understand and treat non-Hodgkin’s lymphoma in head and neck.