艾司西酞普兰与帕罗西汀治疗首发广泛性焦虑对照研究

目的 比较艾司西酞普兰与帕罗西汀治疗首发广泛性焦虑的疗效及不良反应.方法 对符合CCMD-3首发广泛性焦虑诊断标准的48例患者随机分为两组,并分别给予艾司西酞普兰与帕罗西汀治疗6周,对所有患者于治疗前,治疗后1、2、4、6周末用Hamilton焦虑量表(HAMA)及不良反应量表(TESS)进行疗效及不良反应评定.结果 对首发广泛性焦虑的治疗,艾司西酞普兰组有效率92%,帕罗西汀组有效率91.3%;两组疗效比较,差异无统计学意义(P>0.05).一周末艾司西酞普兰组HAMA评分与帕罗西汀组HAMA评分比较,差异有统计学意义(P<0.05).不良反应两组比较,差异无统计学意义.结论 艾司西酞普兰与帕罗西汀疗效相当,艾司西酞普兰起效快,不良反应轻,值得临床推广.

Study on the clinic efficacy of escitalopram and paroxetine in treating patients with first episode generalized anxiety disorder

Objective To investigate the clinic efficacy and side effects of escitalopram and paroxetine in treating patients with first episode generalized anxiety disorder. Methods Forty - eight patients meeting CCMD - 3 criteria of first episode generalized anxiety disorder were randomly divided into two groups. Patients in study group were treated with escitalopram and the control group were treated with paroxetine. The treatment course was 6 weeks. All the subjects were rated by Hamilton Rating Scale for Anxiet （HAMA） and TESS at the baseline and the end of week 1,2, 4, 6, respectively. Results The effective rates of escitalopram group and paroxetine group were 92% and 91.3% in treating first episode generalized anxiety disorder, with no significant difference between two groups（P 〉 0. 05）, but significant difference in the HAMA score by the end of wk 1 （P 〈 0. 05）. There were no significant difference between two groups for the adverse reactions. Conclusion Escitalopram and paroxetine are safe and effective for the treatment of first episode generalized anxiety disorder, but escitalopram possesses more quick response.