| 反复短暂心肌缺血及联合应用戊脉安对急性心肌梗塞再灌注的影响 |
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| 引用本文： | 罗自强,凌宏. 反复短暂心肌缺血及联合应用戊脉安对急性心肌梗塞再灌注的影响[J]. 武汉大学学报(医学版), 1990, 0(3) |
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| 作者姓名： | 罗自强 凌宏 |
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| 作者单位： | 湖南医科大学生理教研室，湖北医学院病生学教研室 |
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| 摘 要： | 心肌反复短暂缺血或戊脉安均可抑制急性心肌梗塞(AMI)再灌注后血小板聚集功能的增强及血浆 TXB_2水平的增高反应,并缩小其梗塞灶。而反复短暂心肌缺血联合应用戊脉安既不能进一步降低 AMI 再灌注后的血小板聚集功能及血浆 TXB_2水平,也不能进一步缩小其梗塞灶。
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| 关 键 词： | 心肌梗塞/病理学 冠状动脉疾病/病理学 维拉帕米/药效学 血小板凝集/药物作用 兔 动物,实验 |
The Effects of Repetitive Brief Episodes of Ischemia and Its Combination with Verapamil on Reperfusion of AMI in Rabbits |
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| Luo Ziqiang. The Effects of Repetitive Brief Episodes of Ischemia and Its Combination with Verapamil on Reperfusion of AMI in Rabbits[J]. Medical Journal of Wuhan University, 1990, 0(3) |
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| Authors: | Luo Ziqiang |
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| Abstract: | The effects of repetitive brief episodes of ischemia and its combination with verapamil on acute mycardial infarct-reperfusion(AMI-R)were studied in open-chest rabbits. These data indicate that preconditioning repetitive brief ischemia or verapamil can limit the infarct size and inhibit the increas- ing reaction of platelet aggregation and plasma TXB_2 level after AMI-R. But verapamil could not fur- ther decrease the infarct size or the platelet aggregation and plasma TXB_2 level after AMI-R precondi- tioned with repetitive brief episedes of ischemia. |
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| Keywords: | myocardial infarction/PA coronary disease/PA verapamil/PD platelet aggregation/DE rabbits animal laboratory |
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