| MIF基因-173位点G/C多态性与子宫内膜异位症遗传易感性的研究 |
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| 引用本文： | 王春平,石丽萍,于雅,石瑾秋,康春阳,许学岚.MIF基因-173位点G/C多态性与子宫内膜异位症遗传易感性的研究[J].中国妇幼保健,2011,26(25):3925-3927. |
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| 作者姓名： | 王春平 石丽萍 于雅 石瑾秋 康春阳 许学岚 |
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| 作者单位： | 广东省深圳市罗湖区人民医院妇产科,518001 |
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| 基金项目： | 深圳市罗湖区科技局立项课题 |
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| 摘 要： | 目的:探讨MIF基因-173位点G/C多态性与子宫内膜异位症的遗传易感性的相关性。方法:应用聚合酶链反应-限制性片断长度多态性技术(PCR-RFLP分析技术)检测广东籍汉族生育期妇女子宫内膜异位症患者49例(内异症组)和非子宫内膜异位症者49例(对照组)的MIF基因-173位点G/C单核苷酸多态性。结果:①内异症组MIF基因-173位点GG、GC、CC 3种基因型分布频率分别为53.06%、34.69%、12.25%;对照组MIF基因-173位点GG、GC、CC 3种基因型的分布频率分别为61.23%、32.65%、6.12%,两组间基因型的分布频率比较差异无统计学意义(P>0.05)。②MIF基因-173位点G、C等位基因型在内异症组中的分布频率分别为70.41%、29.59%,在对照组中分别为77.55%、22.45%,两组间等位基因型频率比较差异无统计学意义(P>0.05)。结论:MIF基因-173位点G/C多态性可能与广东汉族妇女人群子宫内膜异位症的遗传易感性无关。
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| 关 键 词： | 子宫内膜异位症 巨噬细胞移动抑制因子 基因多态性 疾病遗传易感性 |
Study on G/C polymorphism of-173 locus in MIF gene and hereditary susceptibility of endometriosis |
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| WANG Chun-Ping,SHI Li-Ping,YU Ya et al.Study on G/C polymorphism of-173 locus in MIF gene and hereditary susceptibility of endometriosis[J].Maternal and Child Health Care of China,2011,26(25):3925-3927. |
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| Authors: | WANG Chun-Ping SHI Li-Ping YU Ya |
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| Institution: | WANG Chun-Ping,SHI Li-Ping,YU Ya et al.Department of Gynecology and Obstetrics,People's Hospital of Luohu District,Shenzhen 518001,Guangdong,China |
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| Abstract: | Objective:To explore the correlation between G/C polymorphism of-173 locus in macrophage migration inhibitory factor(MIF) gene and hereditary susceptibility of endometriosis. Methods:PCR-PFLP technique was used to detect G/C single nucleotide polymorphisms of-173 locus in MIF gene of 49 women of childbearing age with endometriosis(endometriosis group) and 49 women without endometriosis(control group) of Han nationality in Guangdong. Results:In endometriosis group,the distribution frequencies of GG genotype,... |
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| Keywords: | Endometriosis Macrophage migration inhibitory factor Gene polymorphism Hereditary susceptibility |
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