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| 雌激素对绝经后女性冠心病患者血脂及血管内皮功能的影响 | |
| 引用本文： | 李彦芳,吴媚,赵彤. 雌激素对绝经后女性冠心病患者血脂及血管内皮功能的影响[J]. 中国妇幼保健, 2011, 26(25): 3966-3968 |
| 作者姓名： | 李彦芳 吴媚 赵彤 |
| 作者单位： | 1. 吉林省长春市第二医院,130062 2. 沈阳军区大连疗养院 3. 吉林大学中日联谊医院 |
| 摘 要： | 目的:研究雌激素对绝经后女性冠心病患者血脂及血管内皮功能的影响,探讨绝经后女性冠心病患者血脂及血管内皮功能的相关性。方法:将60例绝经后女性冠心病患者随机分为治疗组和对照组各30例,治疗组在常规治疗的基础上服用尼尔雌醇2 mg,2周1次,对照组仅采用常规治疗,均连续服用6个月。于治疗前及治疗后检测血清总胆固醇(TC)、血清三酰甘油(TG)水平,低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)以及血浆内皮素(ET-1)和一氧化氮(NO)水平,并观察疗效。结果:①与治疗前相比,治疗组TC、TG、LDL-C、ET-1水平均明显下降,HDL-C、NO水平明显上升;②与对照组治疗后相比,治疗组TC、TG、ET-1水平均明显下降,HDL-C、NO水平明显上升,差异均有统计学意义(P<0.05);③Pearson相关分析显示,ET-1与TC、TG及LDL-C之间呈正相关,与HDL-C呈负相关;NO与TC、TG及LDL-C之间呈负相关,与HDL-C呈正相关,差异均有统计学意义(P<0.05)。结论:血脂紊乱及血管内皮功能异常可能参与了绝经后女性冠心病的发生和发展,二者具有相关性;雌激素对绝经后冠心病患者的血脂有明显改善,并具有保护血管内皮功能的作用,有利于冠心病的防治。 |
| 关 键 词： | 尼尔雌醇 绝经后 冠心病 血脂 |
Effect of estrogen on blood lipid and vascular endothelial function of postmenopausal women with coronary heart disease |
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| LI Yan-Fang,WU Mei,ZHAO Tong. Effect of estrogen on blood lipid and vascular endothelial function of postmenopausal women with coronary heart disease[J]. Maternal and Child Health Care of China, 2011, 26(25): 3966-3968 | |
| Authors: | LI Yan-Fang WU Mei ZHAO Tong |
| Affiliation: | LI Yan-Fang,WU Mei,ZHAO Tong.The Second Hospital of Changchun City,Changchun 130062,Jilin,China |
| Abstract: | Objective:To study the effect of estrogen on blood lipid and vascular endothelial function of postmenopausal women with coronary heart disease,explore the correlation between blood lipid and vascular endothelial function in postmenopausal women with coronary heart disease. Methods:60 postmenopausal women with coronary heart disease were divided into treatment group and control group,30 women in each group,the women in treatment group were treated with oral administration of nilestriol(2 mg) biweekly on the ... |
| Keywords: | Nilestriol Postmenopause Coronary heart disease Blood lipid |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |