宫颈癌术前动脉灌注化疗栓塞术的临床观察

目的探讨动脉灌注化疗栓塞术作为宫颈浸润癌术前新辅助化疗的临床疗效。方法 对在湖北省孝感市中心医院诊治的ⅠB2~ⅢA期宫颈癌患者53例进行回顾性分析。术前行动脉介入化疗栓塞术（介入组）32例,行PVB方案全身化疗（全身化疗组）21例。比较两组近期疗效、不良反应、可手术率、化疗结束至根治性手术实施间隔时间、活动性大出血止血效果及术后病检结果进行对比。结果介入组总反应率、化疗住院天数、化疗副反应、可实施手术的时间与全身化疗组比较,差异有统计学意义（P〈0.01）。结论动脉灌注化疗栓塞术对于ⅠB2~ⅢA期宫颈癌患者,特别是活动性大出血的病例,可以达到迅速止血并短期内缩小病灶的良好结局,为尽快手术创造了条件,通过根治性手术,也尽早了解到有关预后的相关因素,为术后治疗方案的制定提供了依据。

The effect of intra-arterial chemo-embolization as a neoadjuvant chemotherapy in the treatment of cervical cancer

Objective To explore the clinical effects of chemo-embolization as a neoadjuvant chemotherapy(NACT) in cervical cancer.Methods Data of 53 cancer patients with stage ⅠB2～ⅢA cervical cancer who were treated in our hospital was analyzed retrospectively.32 cases received intra-arterial chemo-embolization(NACT group) and 21 cases received intra-venous chemotharopy with PVB(IV group).The clinical effects were evaluated by short-term effect,toxic side effect,the operative rate,the period after NACT to radical surgery,the hemostalic effects of active bleeding and pathology after surgery.Results There were significant differences in response rate,NACT time,toxic side effect,the period after NACT to radical surgery,(P<0.01) while there were no significant differences in age,the operative rate,hospitalization costs between the two groups.Conclusions NACT can stop bleeding quickly and reduce the lesion in short term that may provide opportunity of surgery for patients with advanced stages.