帕瑞昔布钠与氟比洛芬酯用于无痛人流术后镇痛的效果比较

目的:比较静脉注射帕瑞昔布钠(parecoxi-sodium)与氟比洛芬酯用于无痛人流术后镇痛的临床效果。方法:将ASAⅠ～Ⅱ、年龄19～47岁的拟行无痛人流手术者60例随机分为Ⅰ组30例术后静脉注射帕瑞昔布钠40 mg和Ⅱ组30例术后静脉注射氟比洛芬酯50 mg。观察术后疼痛强度(VAS评分)、不良反应和病人对镇痛的满意度。结果:与氟比洛芬酯组相比,帕瑞昔布钠组术后VAS评分降低(P<0.05),术后24 h满意度明显提高(P<0.05)。术后帕瑞昔布钠组不良反应发生率较氟比洛芬酯组明显降低,差异有统计学意义(P<0.05)。结论:无痛人流术后静脉给予帕瑞昔布钠40 mg镇痛效果优于静脉注射氟比洛芬酯50 mg,并可降低不良反应的发生率。

The comparison of clinical effectiveness of postoperative analgesia between parecoxib -sodium and flurbiprofen for the painless induced abortion

Objective:To compare clinical effectiveness of parecoxib-sodium and flurbiprofen on patients of postoperative analgesia for painless induced abortion. Methods:60 patients,ASAⅠorⅡ,aged 19~47 years,scheduled for elective painless induced abortion were randomly divided into three groups(n=30): parecoxib-sodium group(groupⅠ)received intravenous parecoxib-sodium 40 mg immediately after operation;flurbiprofen group(groupⅡ)received intravenous flurbiprofen 50 mg immediately after operation.The intensity of pain was measured using VAS score,the adverse effects and the degreed of the satisfied patients in all were recorded. Results:The percentage of the patients who need postoperative analgesia,and the VAS scores of the patients after operation were significantly less in groupⅠthan groupⅡ(P<0.05)..And the percentage of patients' adverse effects in groupⅠ was more reduced than groupⅡ(P<0.05). Conclusion:Compared with flurbiprofen 50 mg,parecoxib 40 mg given in vein after painless induced abortion can reduce the percentage of the patients with the adverse effects and improve postoperative analgesia effectiveness.