CD4＋T淋巴细胞对肺结核患者血清白蛋白的影响

目的 探讨外周血CD4⁺ T淋巴细胞对肺结核患者血清白蛋白的影响。 方法 对119例初治肺结核患者进行淋巴细胞亚群和血清白蛋白测定，探讨细胞免疫功能与血清白蛋白相关性；同时，根据其CD4⁺ T淋巴细胞亚群水平，分为免疫低下组62例和正常组57例，探讨细胞免疫功能低下对低蛋白血症的影响。 结果 （1）所有纳入患者外周血CD4⁺ T淋巴细胞［（516.6±266.1）×10⁹/L］与CD3⁺ T淋巴细胞［（841.6±398.8）×10⁹/L］、CD8⁺ T淋巴细胞［（261.0±142.6）×10⁹/L］、CD4⁺/CD8⁺ T淋巴细胞比值（2.33±1.40）呈正相关（分别为r=0.883，P=0.000；r=0.579，P=0.000；r=0.365，P=0.000）。（2）外周血CD4⁺T淋巴细胞与血清白蛋白呈正相关（r=0.116，P=0.033）。（3）在免疫低下组中，肺部病灶范围达4个肺野以上者43例（占69.4%），明显高于正常组的22例（占38.6%）,差异有统计学意义（χ²=11.335，P=0.001）；免疫低下组治疗前血清白蛋白［（33.9±5.5）g/L］明显低于正常组［（36.1±5.7）g/L］（t=2.187，P=0.031）。 结论 在肺结核患者中CD4⁺ T淋巴细胞与治疗前血清白蛋白水平呈正相关。CD4⁺ T淋巴细胞低下肺结核患者，其病灶范围较广，容易并发低蛋白血症。

The effect of CD4+ T lymphocytes on serum albumin in the patients with puhnonary tuberculosis

Objective To study the effect of CD4+ T lymphocytes on serum albumin in the patients with pulmonary tuberculosis. Methods 119 smear-and culture-positive patients with initially treated pulmonary tuberculosis were detected T lymphocyte subsets and serum albumin.According to the count for CD4+ T lymphocytes,they were divided into two groups: 62 patients in poor immunity group and 57 patients in normal immunity group.We study the effect of poor cellar immunity on hypoproteinemia in the patients. Results(1) CD4...