Effect of biogenic amines and gaba on ATPase activities in mouse tissue |
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| Authors: | Durisala Desaiah Ing K. Ho |
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| Affiliation: | Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216, U.S.A. |
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| Abstract: | ATPase activities were studied in brain, kidney and liver (13,000 x g pellet) fraction from the mouse. Dopamine and norepinephrine added in vitro showed a dose-dependent stimulation of Na+ and K+ activated and oligomycin sensitive Mg2+ ATPase activities in brain but not in kidney and liver tissue fractions. GAB and serotonin had no effect on ATPase in brain, but inhibited oligomycin sensitive Mg2+ ATPase activities in kidney and liver. The relationship between the enhancement of ATPase activity by neurotransmitters in brain and the neuronal excitation is discussed. |
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| Keywords: | γ-Aminobutyric acid ATPase Mouse Brain Liver Kidney Biogenic amines |
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