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Small Cell Gallbladder Carcinoma Complicated by Paraneoplastic Hyponatremia: A Case Report and Literature Review |
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| Authors: | Esther S. Ng Kotamma Venkateswaran Shridhar I. Ganpathi Benjamin Y. Chuah |
| Affiliation: | 1. Department of Medicine, National University Health System, Singapore, Singapore 2. Department of Pathology, National University Health System, Singapore, Singapore 3. Department of Surgery, National University Health System, Singapore, Singapore 4. National University Cancer Institute, Singapore, Singapore 5. National University Hospital, 5 Lower Kent Ridge Road, Main Building Level 2, Singapore, 119074, Singapore |
| Abstract: | IntroductionGallbladder carcinoma has been associated with various paraneoplastic syndromes. These may be the presenting manifestations that lead the clinician to a diagnosis.Case ReportWe report a case of small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia. The hyponatremia was further exacerbated by platinum-based chemotherapy.DiscussionThere have previously been no reports of paraneoplastic hyponatremia in gallbladder carcinoma. We discuss the management of this problem and also provide a short literature review on the other paraneoplastic syndromes associated with gallbladder carcinoma.ConclusionSymptoms and signs of gallbladder cancer may be insidious. Thorough workup is needed if the patient presents with symptoms and signs of a paraneoplastic syndrome. |
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