甲醛对小鼠肺组织超氧化物歧化酶活性、丙二醛含量的影响

目的　探讨甲醛对小鼠肺组织超氧化物歧化酶 (SOD)活性、丙二醛 (MDA)含量的影响。方法　将 36只小鼠随机分成对照组和 2 0、4 0、6 0、80、1 0 0mg m3剂量组 ,采用静式呼吸道染毒 ,连续染毒 35d ,每天 2h ,染毒结束后将小鼠处死 ,测定其肺组织SOD活性 ,MDA含量。结果　与对照组相比 ,各剂量组小鼠肺组织内SOD活性均明显降低 ,MDA含量均明显升高 (P <0 0 1 )。且各剂量组之间SOD活性随染毒剂量的增加而降低 ,MDA含量随染毒剂量的增加而增加 ,但受试物组间经统计学比较差异无显著性 (P >0 0 5 )。结论　吸入一定浓度甲醛即可引起小鼠肺组织SOD活性、MDA含量产生明显变化

The Effect of Formaldehyde on the Activity of SOD and the Concentration of MDA in the Lung Tissue of Mice

Objective To detect the effect of formaldehyde on the activity of superoxide dismutase (SOD) and the concentration of malondialdehyde (MDA) in the lung tissue of the mice after they were made to inhale different amount of formaldehyde. Methods 36 mice were randomly divided into 6 groups, one of which was for control, and the other five were 20,40,60,80 and 100mg/m 3 dose group respectively.The mice were killed after they were given inhalation exposure of formaldehyde in a peaceful environment for 35 days,2 hours per day and then the activity of SOD and the concentration of MDA in the lung were measured. Results The activity of SOD in different dose groups was significantly lower than that of the control group, and the concentration of MDA were remarkably higher ( P <0 01). The activity of SOD and the concentration of MDA had no remarkable differences between the different dose groups( P >0 05), but the former showed an reduced activity, and the latter showed a higher concentration with the dosage up. Conclusion This study suggested that the activity of SOD and the concentration of MDA in the lung tissue of mice could change remarkably after they were given inhalation exposure of some amount of formaldehyde.