| 蛇毒的抗肿瘤活性成分研究进展 |
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| 引用本文： | 李晓红,蔡绍晖,任先达. 蛇毒的抗肿瘤活性成分研究进展[J]. 中国病理生理杂志, 2004, 20(10): 1938-1941 |
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| 作者姓名： | 李晓红 蔡绍晖 任先达 |
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| 作者单位： | 暨南大学药学院药代动力学教研室，广东 广州 510632 |
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| 基金项目： | 国家自然科学基金资助项目 (No .39770 30 0 ) |
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| 摘 要： | Many snake venoms contain complex mixtures of pharmacologically important molecules,some of which show potential therapeutic value in the treatment of cancer and other human disorders. In this review,we mainly reports the effects of snake venom active components, such as disintegrins and lectins in paralyzing cancer cells, blocking on cell migration, interaction with integrins, inhibition of tumor dissemination and angjogenesis. The advanced researches on the snake venom‘s apoptosis- inducing components on tumors are also introduced.
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| 关 键 词： | 蛇毒液类 粘连 血管生成 病理性 细胞凋亡 肿瘤 |
| 文章编号： | 1000-4718(2004)10-1938-04 |
| 收稿时间： | 2003-01-03 |
| 修稿时间： | 2003-05-13 |
Progresses on antitumor effect of snake venom active components |
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| LI Xiao-hong,CAI Shao-hui,REN Xian-da. Progresses on antitumor effect of snake venom active components[J]. Chinese Journal of Pathophysiology, 2004, 20(10): 1938-1941 |
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| Authors: | LI Xiao-hong CAI Shao-hui REN Xian-da |
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| Affiliation: | Department of Pharmacokinetics, Pharmacy College of Jinan University, Guangzhou 510632, China |
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| Abstract: | Many snake venoms contain complex mixtures of pharmacologically important molecules, some of which show potential therapeutic value in the treatment of cancer and other human disorders. In this review, we mainly reports the effects of snake venom active components, such as disintegrins and lectins in paralyzing cancer cells, blocking on cell migration, interaction with integrins, inhibition of tumor dissemination and angiogenesis. The advanced researches on the snake venom's apoptosis-inducing components on tumors are also introduced. [ |
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| Keywords: | Snake venoms Adhesions Angiogenesis pathologic Apoptosis Neoplasms |
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