DEFECTIVE NEUTROPHIL CHEMOTAXIS AND HYPERIMMUNOGLOBULINEMIA E—A REVERSIBLE DEFECT?

Abstract. An eleven-month-old boy is presented with chronic atopic dermatitis and recurrent infections of the skin and respiratory tract, including subcutaneous abscesses. Immunological studies disclosed a neutrophil chemotactic defect, blood eosinophilia and serum hyper IgE. The clinical and analytical data are similar to those of patients previously described by Hill & Quie. A diet free of the allergens which were responsible for the atopic dermatitis reversed the chemotactic defect, the blood eosinophilia and the clinical symptoms.