| 胃癌组织中肝素酶mRNA的原位表达与胃癌转移的关系 |
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| 引用本文： | 唐琳,陈奎生,张蕾,高冬玲,张云汉. 胃癌组织中肝素酶mRNA的原位表达与胃癌转移的关系[J]. 郑州大学学报(医学版), 2004, 39(2): 185-187 |
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| 作者姓名： | 唐琳 陈奎生 张蕾 高冬玲 张云汉 |
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| 作者单位： | 河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052;河南省肿瘤病理重点实验室,郑州大学第一附属医院病理科,郑州,450052 |
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| 基金项目： | 河南省医学科技创新人才工程项目 2003112007,“十五”“211工程”重点学科建设项目 教重办(2002)第2号 |
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| 摘 要： | 目的:探讨肝素酶(HPA)mRNA表达与胃癌转移的关系。方法:采用原位杂交技术检测36例胃腺癌组 织、相应癌旁组织及111例正常胃组织HPA mRNA的表达。结果:正常胃组织、癌旁和胃癌组织HPA mRNA阳性表达率分别为9.1％、33.3％和72.2％,3者间差异均有统计学意义(P<0.05)。有淋巴结转移组的癌及癌旁组织中HPA mRNA阳性表达率分别为88.9％,40.7％。无淋巴结转移组癌及癌旁组织中阳性表达率分别为22.2％,11.1％,2组间差异均有统计学意义(P<0.05)。结论:HPA mRNA高表达可作为判断胃癌转移的有益指标。
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| 关 键 词： | 胃肿瘤 腺癌 肝素酶 转移 |
| 修稿时间： | 2003-10-22 |
Study of relation between expression in situ of heparanase mRNA and metastasis of gastric carcinoma |
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| TANG Lin,CHEN Kuisheng,ZHANG Lei,GAO Dangling,ZHANG YunhanHenan Key Laboratory of Tumor Pathology. Study of relation between expression in situ of heparanase mRNA and metastasis of gastric carcinoma[J]. Journal of Zhengzhou University: Med Sci, 2004, 39(2): 185-187 |
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| Authors: | TANG Lin CHEN Kuisheng ZHANG Lei GAO Dangling ZHANG YunhanHenan Key Laboratory of Tumor Pathology |
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| Affiliation: | TANG Lin,CHEN Kuisheng,ZHANG Lei,GAO Dangling,ZHANG YunhanHenan Key Laboratory of Tumor Pathology,Department of Pathology,the First Affiliated Hospital,Zheng-zhou University,Zhengzhou 450052 |
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| Abstract: | Aim : To investigate the relation between heparanase ( HPA) mRNA expression and the metastasis of gas-trie carcinoma(GC). Methods: The expression of heparanase mRNA in 36 gastric paracancer and cancer tissues, and 11 normal gastric tissues were detected by in situ hybridization. Results: Positive expression rates of HPA mRNA in the normal gastric tissue, paracancer tissue, and cancer tissue were 9. 1% , 33.3% and 72.2% , respectively. The differences a-mong them were significant (P <0. 05). The positive rates of HPA mRNA in group of cancer and paracancer tissue with lymph node metastasis were 88.9% , 40.7% , which were much higher than those in group without lymph node metastasis (22. 2% , 11.1%). Conclusion : The expression of HPA mRNA is a useful marker in predicting the metastasis of GC. |
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| Keywords: | gastric neoplasm adenocarcinoma heparanase metastasis |
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