| 慢性乙型肝炎血清胆碱酯酶与炎症分级及纤维化的临床关系研究 |
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| 引用本文： | 唐振祥,冼永超,程晓雯,程书权.慢性乙型肝炎血清胆碱酯酶与炎症分级及纤维化的临床关系研究[J].中国现代药物应用,2009,3(4). |
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| 作者姓名： | 唐振祥 冼永超 程晓雯 程书权 |
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| 作者单位： | 广西桂林市第三人民医院感染科,541002 |
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| 摘 要： | 目的探讨慢性乙型肝炎(慢乙肝)患者血清胆碱酯酶与肝脏炎症分级及纤维化分期的关系。方法76例经肝活检证实的慢乙肝患者空腹时检测血清CHE、PT、TB等指标,结合肝活检组织炎症分级及纤维化分期,与健康组进行对照研究,分析PT、TB与CHE的相关性。结果肝脏病理组织炎症按程度分为G1～G4级,纤维化程度分为S1～S4期。本组资料显示,患者随着病变炎症程度的加重,CHE值递减,G4、G3、G2组分别与健康组比较,呈现显著性差异(P<0.001),G4、G3与G1组比较亦有显著性差异(P<0.001),但G2与G1组比较差异无显著性(P>0.05),G1组与健康组比较亦无显著性差异。随着纤维化程度的加重,CHE也逐渐下降,纤维化重组(S4+S3)与纤维化轻组(S1+S2)之间比较有显著性差异(P<0.001)。纤维化重组、轻组与对照组比较有显著性差异(P<0.001),PT、TB与CHE有良好相关性,随着PT延长及黄疸程度加深,CHE也逐渐下降。结论CHE与肝脏炎症分级及纤维化分期均有较好的相关性。CHE比TB、PT受病理生理及实验条件等因素的影响较小,能更准确地判断肝脏损害的严重程度,可作为判断慢性乙肝患者病情及预后...
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| 关 键 词： | 慢性乙型肝炎 胆碱酯酶 病理 纤维化 |
Study on the clinical relationship of chronic hepatitis B serum cholinesterase' with inflammamry grading and fibrosis |
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| TANG Zhen-xian,XIAN Yong-chao,CHEN Xiao-wen,CHEN Shu-quan.Study on the clinical relationship of chronic hepatitis B serum cholinesterase' with inflammamry grading and fibrosis[J].Chinese Journal of Modern Drug Application,2009,3(4). |
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| Authors: | TANG Zhen-xian XIAN Yong-chao CHEN Xiao-wen CHEN Shu-quan |
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| Institution: | TANG Zhen-xian; XIAN Yong-chao; CHEN Shu-quan; et al.The Third People s Hospital of Guilin; Guangxi 541002; China; |
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| Abstract: | Objective Study on the relationship of chronic hepatitis B serum cholinesterase with inflammatary grading and fibrosis stage.Method 76 cases of chronic hepatitis B patients for the examnation of CHE、 PT、TB during fasting were confirmed by liver biopsy,with liver biopsy histological inflammatory grade and fibrosis stage,compared with the healthy group,study on correlation between PT,TB and CHE.Result Liver pathological tissue inflammatary grading G1 to G4 and fibrosis stage S1 to S4.This data showed that CHE... |
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| Keywords: | chronic hepatitis B serum cholinesterase pathology fibrosis |
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