805例大肠癌病理与临床分析

目的：探讨本地区大肠癌病理与临床特点。方法：回顾性研究805例大肠癌病理资料，并对青年人大肠癌特点进行分析。结果：本地区大肠癌高峰年龄60～69岁，平均发病年龄55岁。大肠癌发病部位以直肠最多见。肿瘤大体形态溃疡型占58．6％，隆起型37．6％，浸润型3．8％。组织学类型以中分化腺癌最常见(42．9％)，其次为高分化腺癌(32．1％)。Dukes分期低分化腺癌C2期比率分别比高分化腺癌和中分化腺癌高；印戒细胞癌以C2期多见。肿瘤C2期百分比青年组比中年组高，老年组比中年组高，青年组与老年组差别无显著性。直肠癌和乙状结肠癌临床表现以血便为主，降结肠以上肠段癌肿以腹部胀痛多见。结论：本地区大肠癌发病高峰年龄和平均发病年龄比文献报道的晚，青年人大肠癌检出率偏低，青年人大肠癌预后差可能与印戒细胞癌发生率较高有关。

Pathological and Clinical Analysis of 805 Cases of Colorectal Cancer

Objective:To investigate the pathological and clinical features of colorectal cancer.Methods:The pathological data of colorectal biopsy and surgical operation specimens in 805 cases of colorectal cancer were recorded and the histological sections were reviewed and studied.Results:The most common site of the carcinoma was the rectum, regardless of patients' age and sex. Histologically, the major type was moderated differentiated tubular adenocarcinoma. Signet ring cell carcinoma was more common in the younger group than in the older.Conclusion:The median of onset age was about 9 years later than that reported by domestic literature. The incidence of colorectal cancer in younger group in this region was lower than that in some other regions in China.