新生儿败血症甲状腺激素变化及临床意义探讨

目的 :探讨新生儿败血症甲状腺激素变化及临床意义。方法 :观察组 14例新生儿败血症 ,2 1例健康新生儿为对照组。应用放射免疫分析法测定其血清甲状腺激素 (T3 、T4 ) ,游离甲状腺激素 (FT3 、FT4 ) ,促甲状腺激素 (TSH)水平 ,结果进行t检验。结果 :观察组与对照组血清T3 、T4 、FT3 、FT4 之间差异显著 ,FT3 、FT4 差异非常显著 ,各组间TSH均无显著差异。结论 :新生儿败血症可有甲状腺功能改变 ,游离激素变化显著。血清甲状腺激素水平测定可作为机体代谢状况判定、疗效观察和预后估计的一项实验依据。

Study on alteration and clinical significance of thyroid hormones in neonatal sepsis

Objective To investigate the alteration and clinical significance of serum thyroid hormones in neonatal sepsis.Method The concentration of T 3,T 4,FT 3,FT 4and TSH in serum thyroid hormones were tested by radioimmunoassay in 14 cases of sepsis neonates and 21 cases of normal neonates.The results were analyzed by test.Results The concentration of serum T 3,T 4,FT 3,FT 4 in neonatal sepsis were signicantly decreased than in normal control group,especially FT 3,FT 4,But there was no significant difference of TSH between two groups.Conclusion The thyroid function may be changed in neonatal sepsis,especially in free thyroid hormones.The determination of serum thyroid hormones can be used as a laboratory evidence for judging the body's metabolic state,observation of therapeutic effect and evaluation prognosis.