电生理诊断早期原发性开角型青光眼的研究

目的：采用不同空间频率记录原发性开角型青光眼的图像视觉诱发电位（PVEP），图像视网膜电图（PERG）与视网膜-皮质时间（RCT），以发现其敏感的检测指标。方法：用6种空间频率检测11例（17只眼）可疑青光眼，21例（36只眼）原发性开角型青光眼和30例（60只眼）正常组的PVEP，PERG与RCT，然后对其结果进行分析。结果：青光眼组在低空间频率时（0．8cpd），与正常组相比，PERG的b波振幅明显下降，潜伏期延长，振幅的异常率高于潜伏期的异常率。RCT异常率也在低空间频率最高。PVEP在早期青光眼中改变不明显，但可随防青光眼的病情变化。结论：只要采用适当的刺激条件，就可以用电生理检测出早期原发性开角型青光眼。

THE STUDY ON DIAGNOSIS OF EARLY PRIMARY OPEN-ANGLE GLAUCOMA BY ELECTRO PHYSIOLOGICAL METHOD

Objective: Different spatial frequencies were used to record the PVEP,PERG(simultaneously) and RCT on patients with primary open-angle glaucoma(POAG) to find the sensitive testing criterion.Methods: WTBZ]PVEP,PERG and RCT were tested by 6 spatial frequencies on 11 cases(17 eyes) with suspect glaucoma,21 cases(36 eyes) with primary open-angle glaucoma,and 30 cases(60 eyes) of normal controls.The result was analyzed.Results: When the spatial frequency is lower(0.8 cpd),the amplitude of b wave of PERG decreased distinctively,and the latency prolonged in glaucoma group,and the abnormal rate of RCT is higher when compared with the normal controls.The abnormal rate of b wave amplitude is higher than the b wave latency.PVEP is almost normal in suspect glaucoma group and abnormal in glaucoma group when compared with the normal group.Conclusion: Early POAG can be diagnosed by electrophysiological method if proper testing condition is used.