| 光学活性的α-甲基丁酰基间苯三酚类化合物绝对构型与旋光方向的关系及其合成 |
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| 引用本文： | 裴月湖,李铣,朱廷儒. 光学活性的α-甲基丁酰基间苯三酚类化合物绝对构型与旋光方向的关系及其合成[J]. 药学学报, 1989, 24(6): 413-421 |
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| 作者姓名： | 裴月湖 李铣 朱廷儒 |
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| 作者单位： | 沈阳药学院天然药物研究室,沈阳110015 |
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| 摘 要： | 合成了14个新化合物,其中有12个是(S)-(+)-α-甲基丁酰基间苯三酚类化合物。通过对新化合物旋光资料的研究和分析,找到了它们绝对构型与旋光方向的关系。该规律在测定光学活性的α-甲基丁酰基间苯三酚类化合物的绝对构型和开发研究该类药物上,均具有一定的实际应用价值。
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| 关 键 词： | α-甲基丁酰基间苯三酚类化合物 酰基间苯三酚类化物合 光学活性 |
| 收稿时间： | 1988-05-23 |
An empirical correlation between optical rotation and absolute configuration of optically active alpha-methylbutyrylphloroglucinols and its synthesis |
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| YH Pei,X Li and TR Zhu. An empirical correlation between optical rotation and absolute configuration of optically active alpha-methylbutyrylphloroglucinols and its synthesis[J]. Acta pharmaceutica Sinica, 1989, 24(6): 413-421 |
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| Authors: | YH Pei X Li TR Zhu |
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| Abstract: | Fourteen new compounds were synthesized of which twelve are (S)-(+)-alpha-methylbutyrylphloroglucinols. On the basis of optical rotation data and theoretical analysis, an empirical correlation between optical rotation and absolute configuration of optically active alpha-methylbutyrylphloroglucinols has been established by means of Brewster's rule of atomic asymmetry. It can be served as a means of absolute configuration assignment of optically active alpha-methylbutyrylphloroglucinols. |
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| Keywords: | Acylphloroglucinols Optical activity α-Methylbutyrylphloroglucinols |
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