麻醉性镇痛剂及中枢神经刺激剂的分析研究

本文叙述了用高分辨气相色谱法/火焰离子化检测器,气相色谱/氮磷检测器以及气相色谱/质量选择检测器对12种麻醉性镇痛剂和2种中枢神经刺激剂的分析研究。样品用不同衍生化方法作了比较。初步结果表明:衍生化效果TFAA比MBTFA好,但与MSTFA无明显区别。本法对所有14种药物均能获得满意的分离,为筛选这些药物提供了可靠、快速而简易的方法。

STUDIES ON THE ANALYSIS OF SOME NARCOTIC ANALGESICS AND CNS-STIMULANTS

Procedures for the separation and identification of 12 narcotic analgesics and 2 CNS-stimulants are described using GC/FID, GC/NPD and GC/MSD. The TFA and TMS derivatives were prepared by adding TFAA, MB TFA and MSTFA to the standard drugs. The mixture was heated at 70 degrees C for 30 min and chromatographed on FS capillary columns (SE-54, HP-5). Preliminary results show that all the derivatization with TFAA is better than that with MBTFA, but not much different from MSTFA derivatization. The method is reliable, fast and simple and may be used to screen these drugs and further applied to the analysis of biological fluids such as plasma and urine.