| 联苯双酯对人红细胞膜流动性的影响 |
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| 引用本文： | 陈玲,陈文为.联苯双酯对人红细胞膜流动性的影响[J].药学学报,1989,24(1):1-1. |
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| 作者姓名： | 陈玲 陈文为 |
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| 作者单位： | 北京中医学院中心实验室，北京中医学院中心实验室 北京 100013，北京 100013 |
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| 摘 要： | 本文用荧光探剂ANS,NPN和DPH研究联苯双酯对人红细胞膜不同层次流动性的影响。结果表明:该药可降低膜表层流动性(ANS为探剂),增加膜中层(NPN为探剂)和深层(DPH为探剂)的流动性。此外,还发现该药对由丙二醛诱发的溶血有保护作用。综合以上结果,作者对联苯双酯的药理作用进行了扼要的讨论。
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| 关 键 词： | 联苯双酯 膜流动性 膜相变温度 |
| 收稿时间： | 1987-11-07 |
THE EFFECT OF BIPHENYL DIMETHYL DICARBOXYLATE (DDB) ON THE FLUIDITY OF HUMAN ERYTHROCYTE MEMBRANE |
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| L Chen and WW Chen.THE EFFECT OF BIPHENYL DIMETHYL DICARBOXYLATE (DDB) ON THE FLUIDITY OF HUMAN ERYTHROCYTE MEMBRANE[J].Acta Pharmaceutica Sinica,1989,24(1):1-1. |
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| Authors: | L Chen and WW Chen |
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| Abstract: | This paper deals with the effects of DDB on human RBC membrane fluidity as reflected by changes in the phase transition temperature and microviscosity monitored by ANS, NPN and DPH The results showed that DDB decreased the fluidity of the shallow layer (ANS as probe), but increased the fluidity of the middle layer (NPN as probe) and deeper layer (DPH as probe). In addition the. drug was found to inhibit the hemolysis indnced by MDA. |
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| Keywords: | Biphenyl dimethyl dicarboxylate(DDB) Membrane fluidity Phase transition temperature |
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