| 中药冰片—水杨酸低共熔物透皮吸收研究 |
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| 引用本文： | 崔东贤,杉林坚次,森本雍宪,李风龙. 中药冰片—水杨酸低共熔物透皮吸收研究[J]. 药学学报, 1989, 24(7): 556-558 |
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| 作者姓名： | 崔东贤 杉林坚次 森本雍宪 李风龙 |
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| 作者单位： | 延边医学院药剂学教研室，日本城西大学药学部制剂学教研室，日本城西大学药学部制剂学教研室，延边医学院药剂学教研室 延吉 133000，延吉 133000 |
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| 摘 要： | 某些固体有机药物有和水杨酸类生成低共熔物的特点。本文利用冰片(borneol简称BO)和水杨酸(salicylic acid简称SA)生成低共熔物性质,探讨了BO-SA低共熔物透过大白鼠离体皮肤的效果。实验结果表明BO-SA低共熔物比BO的透皮吸收有明显的增加,为研制冰片透皮吸收制剂提供了方法。
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| 关 键 词： | 透皮吸收 冰片 水杨酸 低共熔物 |
| 收稿时间： | 1988-04-06 |
STUDY ON TRANSDERMAL ABSORPTION OF BORNEOL-SALICYLIC ACID EUTECTIC MIXTURE |
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| DX Cui,K Sugibayashi,Y Morimoto and FL Li. STUDY ON TRANSDERMAL ABSORPTION OF BORNEOL-SALICYLIC ACID EUTECTIC MIXTURE[J]. Acta pharmaceutica Sinica, 1989, 24(7): 556-558 |
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| Authors: | DX Cui K Sugibayashi Y Morimoto FL Li |
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| Abstract: | Borneol is an organic drug having property to form cutectic mixture with salicylic acid.We compared the transdermal absorption rate of borneol alone with that of borneol-salicylic acid eutectic mixture in hairless rats. The results showed that the borneol-salicylic acid eutectic mixture can evidently increase the absorption rate of borneol and provided a method for manufacturing borneol preparation which can easily be absorbed transdermally. |
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| Keywords: | Transdermal absorption Borneol Salicylic acid Eutectic mixture |
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