| 7-(4,7-二取代香豆素-3-乙酰氨基)头孢菌素的合成 |
| |
| 引用本文： | 范华娟,段廷汉,李明华,.7-(4,7-二取代香豆素-3-乙酰氨基)头孢菌素的合成[J].药学学报,1989,24(3):175-181. |
| |
| 作者姓名： | 范华娟 段廷汉 李明华 |
| |
| 作者单位： | 中国药科大学制药化学教研室，中国药科大学制药化学教研室，中国药科大学制药化学教研室 南京 210009 南京医学院化学教研室，南京 210009，南京 210009 |
| |
| 摘 要： | 本文根据构效关系,设计并合成了17个7-(4,7-二取代香豆素-3-乙酰氨基)头孢菌素衍生物。其缩合方法采用酰氯法、Vilsmeier试剂法及混合酐法。初步体外抑菌试验表明,化合物对革兰氏阳性菌和少数革兰氏阴性菌有较强的抗菌作用。进一步药理试验尚在进行。
|
| 关 键 词： | 7-(4 7-二取代香豆素-3-乙酰氨基)头孢菌素 酰氯 Vilsmeier试剂 混合酐 抗菌活性 |
| 收稿时间： | 1988-02-21 |
Synthesis of 7-(4,7-di-substituted coumarin-3-acetamido)cephalosporins |
| |
| HJ Fan,TH Duan and MH Li.Synthesis of 7-(4,7-di-substituted coumarin-3-acetamido)cephalosporins[J].Acta Pharmaceutica Sinica,1989,24(3):175-181. |
| |
| Authors: | HJ Fan TH Duan and MH Li |
| |
| Abstract: | Seventeen derivatives of 7-(4,7-di-substituted conmarin-3-acetamido)cephalosporins were synthesized with acid chloride method, Vilsmeier reagent method and mixed anhydride method. Isolation and purification were fulfilled with Sephadex LH-20 column chromatography and centrifugal-TLC technique. Their chemical structures were identified by elemental analysis, IR and ~1HNMR spectrum. The preliminary antibacterial activity tests showed that these cephalosporin derivatiyes exhibited good activity against Gram-positive bacteria and individual Gramnegative bacteria. Further experiments in pharmacology will be made. |
| |
| Keywords: | 7-(4 7-Di-substituted coumarin-3-acetamido)cephalosporins Acid chloride Vilsmeier reagent Mixed anhydride Antibiotic activity |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
| 点击此处可从《药学学报》下载免费的PDF全文 |
|
