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Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer |
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| Authors: | Howard L Kaufman Seunghee Kim-Schulze Kelledy Manson Gail DeRaffele Josephine Mitcham Kang Seok Seo Dae Won Kim and John Marshall |
| Institution: | (1) The Tumor Immunology Laboratory, Division of Surgical Oncology, Columbia University, New York, NY, USA;(2) The Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA |
| Abstract: | PurposeAn open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability and obtain preliminary data on immune response and survival. |
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