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| 芪蓝颗粒对SD大鼠舌黏膜癌变过程中EGFR变化的影响 | |
| 引用本文： | 陈作良,韩阳平,郑晓斌,陈宏柏,林向党. 芪蓝颗粒对SD大鼠舌黏膜癌变过程中EGFR变化的影响[J]. 临床口腔医学杂志, 2011, 27(2): 73-76. DOI: 10.3969/j.issn.1003-1634.2011.02.003 |
| 作者姓名： | 陈作良 韩阳平 郑晓斌 陈宏柏 林向党 |
| 作者单位： | 1. 福建医科大学教学医院,厦门市口腔医院,福建,厦门,361003 2. 泉州市人民医院口腔科,福建,泉州,362000 3. 厦门市医药研究所,福建,厦门,361003 |
| 基金项目： | 厦门市科技计划项目资助(3502Z20044008) |
| 摘 要： | 目的：探讨中药芪蓝颗粒阻癌抑癌的作用机制。方法：SD大鼠150只,随机分为A、B、C、D、E共5组,A、B、C、D组用0.002%4NQO制备大鼠舌癌变模型,其中B、C、D组在制备模型的同时,用不同剂量芪蓝颗粒进行干预,A组为模型对照组,E组为正常对照组。各组于中药干预的9、18、27、36周时分别处死7只动物,取舌组织光镜下观察其病理变化,采用免疫组化技术检测各组表皮生长因子受体（EGFR）的表达。结果：A组总体癌变率39.29%,明显高于B、C、D组（P〈0.05）。A组中EGFR的表达从正常口腔黏膜→各级异型增生→癌变,其阳性表达率呈递增趋势,差异有统计学意义（P〈0.01）。在大鼠异常增生舌组织中A组的EGFR阳性表达率为6/11明显高于B、C、D组,差异有统计学意义（P〈0.05）。在大鼠舌癌组织中进行中药干预组EGFR的阳性表达明显低于A组（P〈0.05）,差异有统计学意义（P〈0.05）。E组EGFR蛋白表达均为阴性。结论：芪蓝颗粒具有明显的抑癌阻癌效果,它可能通过下调细胞中EGFR的表达水平,起到抑癌阻癌的作用。 |
| 关 键 词： | 芪蓝颗粒 4NQO SD大鼠 舌癌 表皮生长因子受体 |
The influence of Qi-lan granulates on the variation of epidermal growth factor receptor during the course of SD rat tongue carcinogenesis |
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| CHEN Zuo-liang,HAN Yang-ping,ZHENG Xiao-bin,CHEN Hong-bo,LIN Xiang-dang. The influence of Qi-lan granulates on the variation of epidermal growth factor receptor during the course of SD rat tongue carcinogenesis[J]. Journal of Clinical Stomatology, 2011, 27(2): 73-76. DOI: 10.3969/j.issn.1003-1634.2011.02.003 | |
| Authors: | CHEN Zuo-liang HAN Yang-ping ZHENG Xiao-bin CHEN Hong-bo LIN Xiang-dang |
| Affiliation: | CHEN Zuo-liang1,HAN Yang-ping1,ZHENG Xaio-bin2,CHEN Hong-bo1,LIN Xiang-dang3.1.Dental Hospital of Xiamen,Fujian Medical University.Fujian Xiamen 361003,China,2.The People's Hospital of Quanzhou,Stomatological Department,Fujian Quanzhou 362000,3.Xiamen Research Insibitate of Medicine,Fujian Xiamen 361003,China. |
| Abstract: | Objective:To study the cancer blocking effect of the Qi-lan Granulates.Method:A total of 150 SD rats were divided into five groups A,B,C,D,E.Rats in group A,B,C,D were fed with 0.002 % 4NQO dissolved in drinking water to induce tongue carcinogenesis in rats.Different concentration of the herb Qi-lan Grannulates was given to the rats of group B,C,D during oral carcinogenesis.Group A is model group,Group E is normal group.Rats were sacrificed at 9,18,27 and 36 weeks respectively from the begining of the exper... |
| Keywords: | Qi-lan granulates 4NQO SD rat Tongue cancer EGFR |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |