| 大鼠舌癌癌变过程中琥珀酸脱氢酶的表达变化 |
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| 引用本文： | 葛姝云,娄佳宁,周曾同. 大鼠舌癌癌变过程中琥珀酸脱氢酶的表达变化[J]. 临床口腔医学杂志, 2011, 27(1): 20-22. DOI: 10.3969/j.issn.1003-1634.2011.01.007 |
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| 作者姓名： | 葛姝云 娄佳宁 周曾同 |
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| 作者单位： | 1. 上海交通大学医学院附属第九人民医院口腔黏膜科·口腔医学院·上海市口腔研究所·上海市口腔医学重点实验室,上海,200011
2. 上海交通大学附属第一人民医院口腔科,上海,200080 |
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| 基金项目： | 国家自然科学基金青年项目(30700944); 上海市重点学科建设项目基金资助(S30206) |
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| 摘 要： | 目的：探讨大鼠口腔癌变过程中琥珀酸脱氢酶（Succinate dehydrogenase,SDH）的表达及其生物学意义。方法：0.002%4-硝基喹啉-1-氧化物（4NQO）饮水喂养Wistar大鼠9-32周建立大鼠舌癌变模型,用实时荧光定量PCR法检测30例大鼠舌癌变过程不同病理阶段组织中SDH的表达水平。结果：轻度异常增生、中度异常增生、重度异常增生。鳞癌组织病理分级中,中度异常增生、重度异常增生、鳞癌组织中SDH表达显著低于正常黏膜（P〈0.05或P〈0.01）。SDH表达与组织的病理学分级相关（P〈0.01）。结论：SDH基因表达与口腔癌发生发展相关,三羧酸循环在口腔黏膜癌变过程中可能起到重要作用。
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| 关 键 词： | 口腔癌变 琥珀酸脱氢酶 实时荧光定量PCR 4-硝基喹啉-1-氧化物 |
Changes in succinate dehydrogenase gene expression during 4-nitroquinoline 1-oxide induced rat tongue carcinogenesis |
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| GE Shu-yun,LOU Jia-ning,ZHOU Zeng-tong. Changes in succinate dehydrogenase gene expression during 4-nitroquinoline 1-oxide induced rat tongue carcinogenesis[J]. Journal of Clinical Stomatology, 2011, 27(1): 20-22. DOI: 10.3969/j.issn.1003-1634.2011.01.007 |
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| Authors: | GE Shu-yun LOU Jia-ning ZHOU Zeng-tong |
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| Affiliation: | GE Shu-yun,LOU Jia-ning,ZHOU Zeng-tong.1.Department of Oral Medicine,College of Stomatology,Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University,Research Institute of Stomatology,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China,2.Department of Stomatology,First People's Hospital,Shanghai 200080,China. |
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| Abstract: | Objective:To observe the different expression of Succinate dehydrogenase(SDH) during oral carcinogenesis,analyze the relationship between the abnormal expression of SDH,and the occurrence and development of oral carcinogenesis.Method:Real-time quantitative PCR was employed to detect the gene expression of SDH in 38 rat tongue carcinogenesis specimens induced by 4-nitroquinoline 1-oxide.Result:with the progress of tongue carcinogenesis,the expression of SDH was down-regulated.in normal,Mild epithelial dyspla... |
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| Keywords: | oral carcinogenesis Succinate dehydrogenase Real-time quantitative PCR 4-nitroquinoline 1-oxide |
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