孕妇产前注射乙型肝炎免疫球蛋白阻断乙型肝炎病毒宫内感染的临床观察

目的探讨乙型肝炎免疫球蛋白 (HBIG)阻断HBsAg阳性孕妇乙型肝炎病毒 (HBV)宫内感染的疗效。 方法 86例HBsAg阳性孕妇随机分为预防组 (46例 )和对照组 (40例 )。预防组自 2 8周开始每 4周肌注 1次HBIG(2 0 0U)直至分娩。对照组不用上述药物。新生儿出生后检测HBsAg。 结果预防组新生儿HBsAg阳性率为 4 .3% ,明显低于对照组的 2 2 .5 % (P <0 .0 5 )。HBeAg阳性和阴性孕妇均可发生宫内感染 ,HBV DNA阴性孕妇均未发生宫内感染。结论产前应用HBIG可降低HBV宫内感染率。

Clinical observation of blocking HBV intrauterine infection by injection of hepatitis B immunoglobulin before laboring

Objective To study the therapeutic effect of blocking HBV intrauterine infection by injection of hepatitis B immunoglobulin(HBIG) in HBsAg positive pregnant women. Methods 86 HBsAg positive pregnant women were randomly divided into prevention group(46 cases) and control group(40 cases). 28 patients in the prevention group started with the 200U HBIG every 4 weeks from the 28th week till delivery but the patients in the control group were not given HBIG. HBsAg in the newborns was detected. Results The HBsAg positive rate in the newborns of the prevention group was 4.3%, lower than that in control group which was 22.5%(P<0.05). HBeAg positive and negative women suffered from intrauterine infection while the HBV DNA negative patients did not develop intrauterine infection. Conclusion HBIG before laboring can decrease the HBV intrauterine infection rate.