| 补肾壮骨胶囊治疗原发性骨质疏松症的研究 |
| |
| 引用本文： | 陈勇川,彭静,朱卫民,孟萍,方勇飞,艾智华,冯正平,柏干苹. 补肾壮骨胶囊治疗原发性骨质疏松症的研究[J]. 中国组织工程研究与临床康复, 2003, 7(12): 1786-1787 |
| |
| 作者姓名： | 陈勇川 彭静 朱卫民 孟萍 方勇飞 艾智华 冯正平 柏干苹 |
| |
| 作者单位： | 1. 解放军第三军医大学西南医院临床药理基地,重庆市,400038
2. 成都军区总医院药剂科,四川省成都市,610083 |
| |
| 摘 要： | 目的观察补肾壮骨胶囊治疗原发性骨质疏松症的安全性和有效性。方法采用双盲、双模拟、平行对照法,48例原发性骨质疏松症患者分别服用补肾壮骨胶囊1.458/粒,2粒/次,3次/d)和骨松宝颗粒(10g/袋,1袋/次,3次/d)。6个月后分析疗效。结果补肾壮骨胶囊的临床显效率和总有效率分别为50%和100%,与对照药骨松宝颗粒相同。经双能X线骨密度检测,补肾壮骨胶囊可使原发性骨质疏松症患者L2～4的骨密度(g/cm2)由0.71±0.06提高到0.75±0.07(t=-2.08,P<0.05);股骨粗隆的骨密度由0.65±0.01提高到0.71±0.09(t=2.09,P<0.05)。两组患者治疗前后血清钙、血清磷、碱性磷酸酶、尿钙、尿羟脯氨酸水平差异无显著性意义(t=0.5～1.19,P>0.05)。两组不良反应发生率也无显著性差异(χ2=1.03,P>0.05)。结论补肾壮骨胶囊治疗原发性骨质疏松症,其机制为提高患者的骨密度、抑制骨吸收、减少骨量丢失。
|
| 关 键 词： | 骨质疏松 植物 药用 病例对照研究 双盲法 |
| 文章编号： | 1671-5926(2003)12-1786-02 |
| 修稿时间： | 2003-03-17 |
A randomized controlled double-blind study of Bushenzhuanggu capsule for the treatment of primary osteoporosis |
| |
| Chen Yongchuan,Peng Jing,Zhu Weimin,Meng Ping,Fang Yongfei,Ai Zhihua,Feng Zhengping,Bo Ganping Chen Yongchuan,Zhu Weimin,Meng Ping,Fang Yongfei,Ai Zhihua,Feng Zhengping,Bo Ganping,Clinical Pharmacology Base of Southwestern Hospital,Third Military Medical University,Chongqing ,China Peng Jing. A randomized controlled double-blind study of Bushenzhuanggu capsule for the treatment of primary osteoporosis[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(12): 1786-1787 |
| |
| Authors: | Chen Yongchuan Peng Jing Zhu Weimin Meng Ping Fang Yongfei Ai Zhihua Feng Zhengping Bo Ganping Chen Yongchuan Zhu Weimin Meng Ping Fang Yongfei Ai Zhihua Feng Zhengping Bo Ganping Clinical Pharmacology Base of Southwestern Hospital Third Military Medical University Chongqing China Peng Jing |
| |
| Affiliation: | Chen Yongchuan,Peng Jing,Zhu Weimin,Meng Ping,Fang Yongfei,Ai Zhihua,Feng Zhengping,Bo Ganping Chen Yongchuan,Zhu Weimin,Meng Ping,Fang Yongfei,Ai Zhihua,Feng Zhengping,Bo Ganping,Clinical Pharmacology Base of Southwestern Hospital,Third Military Medical University,Chongqing 400038,China Peng Jing,Department of Pharmaceutical,General Hospital of Chengdu Military Area,Chengdu 610083,China |
| |
| Abstract: | |
| |
| Keywords: | osteoporosis plants medicinal case control studies double blind method |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
