硝酸咪康唑与氟康唑治疗重度外阴阴道念珠菌病的疗效观察

目的探讨重度外阴阴道念珠菌病（VVC）的临床特征及硝酸咪康唑栓1 200 mg两次疗法与氟康唑150 mg两次疗法治疗重度外阴阴道念珠菌病的效果。方法根据Sobel分类,将245例重度VVC患者随机分为两组：硝酸咪康唑组,123例,使用硝酸咪康唑阴道软胶囊1 200 mg睡前阴道用药,72 h加用一粒;氟康唑组,122例,使用氟康唑150 mg口服,72 h后加服150 mg。于治疗完成后第7-14 d和28-35 d进行真菌学疗效评价。结果硝酸咪康唑和氟康唑对重度VVC的近期真菌学治愈率分别为90.27%（102/113）和87.72%（100/114）（P〉0.05）;远期真菌学治愈率分别为76.11%（86/113）和70.18%（80/114）（P〉0.05）。白念珠菌在重度VVC致病菌中所占的比例为93.06%（228/245）。硝酸咪康唑不良反应的发生率为1.63%（2/123）,氟康唑组未见明显不良反应。结论硝酸咪康唑栓1 200 mg两次疗法治疗重度VVC安全有效。白念珠菌是重度外阴阴道念珠菌的主要致病菌。

Treatment of severe vulvovaginal candidiasis and the comparative study of the mycological efficacy of miconazole nitrate and fluconazole

Objective To determine the clinical manifestations of severe VVC and to study the mycological efficacy of miconazole nitrate 1200 mg vaginal ovule with fluconazole 150mg for severe VVC.Methods According to Sobel classify,a prospective randomized and comparative study were conducted among 245 patients with severe VVC.123 patients received miconazole nitrate 1200 mg vaginal ovule before sleeping and another 1200mg after 72 hours,and 140 patients received oral fluconazole 150mg and another 150mg after 72 hours...