托吡酯单药治疗难治性癫痫的临床观察

目标维持剂量100mg,初始剂量为25mg,qd。基础期4周,记录发作次数;加药期4~8周,稳定期12周。30例并联用其他抗癫痫药作为对照。记录发作情况及不良反应。结果单药治疗组控制率65.6%,显效率78.1%,不良反应发生率50.0%,多数较轻微且短暂;联合用药组分别为13.3%、20.0%和83.3%。2组比较差异有显著性(P<0.05)。结论TPM单药治疗癫痫是安全、有效的方法。

Clinical efficacy of topiramate monotherapy in treatmnt of intractable epilepsy

Objective To assess the efficacy and safety of Topiramate (TPM)monotherapy in patients with intractable epilepsy(IE).Methods 32 patients were given TPM monotherapy(25mg once a day),the targeted dosage was 100mg TPM.There were 3 periods to reach the goal dosage:the baseline period(4weeks) to observe the seizure rate;the increase period(4~8 weeks) to increase dose to the goal dosage;the dose maintain period was 12 weeks. 30 patients were given TPM combined with other antiepileptics as control.Results In the active group 65.6% patients became seizure-free and the significaant effective rate was 78.1% with the incidence of side effect being 50%,most of which were mild and transient.In the control group the above three indexes were 13.3%,20.0%and 83.3%respectively.There was significant difference between the two groups( P <0.05).Conclusion TPM is an effective and safe agent for treatment of epilepsy.