Correlation of MicroRNA 17-92 Cluster Host Gene (MIR17HG) Polymorphisms With Susceptibility and Prognosis for Multiple Myeloma |
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| Institution: | 1. Department of Emergency Medicine, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;2. Department of Oncology, Hangzhou Hospital of Traditional Chinese Medicine, Guangxing Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Province, China;1. Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang, Ouhai District, Wenzhou, China;2. Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang, Ouhai District, Wenzhou, China;3. Laboratory of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang, Ouhai District, Wenzhou, China;1. Division of Hematology-Oncology, Department of Medicine, University of Arizona Cancer Center, Tucson, AZ;2. University of Arizona Cancer Center, Tucson, AZ;3. Department of Medicine, Division of Hematology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL;1. Department of Oncological Intensive Care and Emergencies & Thoracic Oncology, Université Libre de Bruxelles (ULB), Brussels, Belgium;2. Data Centre, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium;3. Laboratory of Molecular and Cellular Biology, Gembloux, Université de Liège, Belgium;4. Department of Pneumology, CHU Lille, Lille, France;1. Catholic Blood and Marrow Transplantation Center, Seoul St Mary’s Hospital, The Catholic University of Korea, Seoul, Korea;2. Leukemia Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea;3. Yeoido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea;4. Incheon St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea;1. Division of Hematology & HCT, Department of Oncology, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia;2. King Abdullah International Medical Research Center;3. King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia;4. Department of Medical Imaging, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia |
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| Abstract: | PurposeTo explore the correlation of MIR17HG polymorphism with susceptibility and prognosis of multiple myeloma (MM).Patients and MethodsA total of 217 MM patients treated with high-dose melphalan combined with autologous peripheral blood stem-cell transplantation at our hospital were enrolled as the case group, and 220 healthy people were included as the control group. Sequenom MassARRAY iPLEX Gold single nucleotide polymorphism genotyping was used to detect polymorphisms of MIR17HG, including rs7336610, rs17735387, rs4284505, and rs1428.ResultsAn increased risk of MM was found in patients who carried the rs7336610 T allele and rs4284505 G allele, and the higher the Durie-Salmon and International Staging System stages were, the more MM patients carrying rs7336610 CT + TT genotype and rs4284505 AG + GG genotype (all P < .05). Haplotype AC (rs4284505-rs1428) and CA (rs7336610-rs4284505) evidently reduce MM risk, whereas haplotype GC (rs4284505-rs1428) significantly elevated MM risk (all P < .05). Kaplan-Meier curve analysis demonstrated that rs7336610 CC genotype carriers had higher 5-year survival rate than CT + TT genotype carriers (P = .034), and the AA genotype carriers of rs4284505 had higher 5-year survival rate than AG + GG genotype carriers (P < .001).ConclusionPolymorphisms of MIR17HG rs7336610 and rs1428 were correlated with MM risk and prognosis. |
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| Keywords: | Clinical Parameters Genetic polymorphism Genotyping Haplotype MicroRNAs |
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