微量白蛋白尿与代谢综合征及其组分的关联性研究

  目的  分析微量白蛋白尿(microalbuminuria, MAU)与代谢综合征及其组分的关系。  方法  2017年，在江苏省和山东省的4个调查点开展减盐防控高血压项目终末调查，调查对象通过多阶段整群随机抽样的方式抽取，年龄为18~75岁的常住人口。通过24 h尿白蛋白测定法测算MAU，并使用logistic回归分析模型分析MAU与代谢综合征(metabolic syndrome, MS)及其组分的关联。  结果  共纳入研究对象1 193名，年龄(49.4±12.6)岁，其中男性558人，占46.8%，MAU检出人数为112人，占9.4%，MS者375人，占31.4%。logistic回归分析模型校正相关混杂因素后，与非MS组相比，MS组MAU患病风险更高(OR=3.188, 95% CI: 2.123~4.790)，且MS各组分中心性肥胖、血压升高和GLU升高均与MAU患病风险呈正相关。在对相关因素校正后，与不具有MS组分者相比，具有3、4和5个MS组分者MAU患病风险更高(OR=4.839, 95% CI: 2.134~10.976;OR=5.185, 95% CI: 2.153~12.487;OR=7.242, 95% CI: 2.243~23.383) (P_趋势 < 0.001)。  结论  MAU与MS及其组分患病风险呈正相关。

Association of microalbuminuria with metabolic syndrome and its components

  Objective  To analyze the association of microalbuminuria (MAU) with metabolic syndrome and its components.  Methods  In 2017, data were derived from the final survey of the Shandong Ministry of Health Action on Salt Reduction and Hypertension Project, which was a survey conducted at four sites in the Jiangsu and Shandong Provinces. The participants, which consisted of permanent residents aged 18 to 75 years, were selected through multi-stage cluster random sampling. MAU was measured using the 24 hour urinary albumin excretion. Logistic regression was used to analyze the association between MAU and metabolic syndrome (MS) and its components.  Results  A total of 1 193 participants were included, with a mean age of (49.44±12.59) years. Of these, 558 (46.8%) were males, and 112 (9.4%) had MAU, and 375 (31.4%) had MS. Logistic regression analysis found that compared with the group without MS, group with MS had an increased risk being MAU (OR=3.188, 95% CI: 2.123-4.790). And in MS cases, the central obesity, elevated blood pressure, elevated fasting glucose were positively associated with the risk of MAU after adjusting for relevant factors. Moreover, compared with the group without MS, group with 3, 4 and 5 MS components had an increased risk being MAU (OR=4.839, 95% CI: 2.134-10.976; OR=5.185, 95% CI: 2.153-12.487; OR=7.242, 95% CI: 2.243-23.383), respectively (P_trend < 0.001), after adjusting for relevant factors.  Conclusions  There is a positive association between MAU and the risk of MS and its components.