早期创伤性颅脑损伤病人血浆NT-proBNP水平与疾病严重程度及预后的关系分析

目的：探讨创伤性颅脑损伤病人早期血浆氨基末端脑钠肽前体(NT-proBNP)水平与疾病严重程度及其预后的关系。方法：采用回顾性研究方法，选取100例创伤性颅脑损伤病人为观察组，记录病人发病2、12、24 h时的血浆NT-proBNP水平，分析其变化特点。根据病人入院时的格拉斯哥昏迷评分(GCS)将创伤性颅脑损伤病人分为轻型组、中型组、重型组，比较3组病人不同时间的血浆NT-proBNP水平，探讨血浆NT-proBNP水平与疾病的严重程度的相关性。发病30 d依据格拉斯哥预后评分(GOS)将颅脑损伤病人分为预后不良组和预后良好组，比较不同预后病人的血浆NT-proBNP水平特点。结果：发病2、12、24 h, 3组间血浆NT-proBNP水平，差异均有统计学意义(P<0.01),轻型组低于其他两组，中型组低于重型组(P<0.01);3组组内在发病2、12、24 h时血浆NT-proBNP水平差异均有统计学意义(P<0.01),轻型组发病12、24 h时均明显高于发病2 h时(P<0.01),中型组发病24 h均明显高于发病2、12 h时(P<0.01),重型...

Analysis of relationship between plasma NT-proBNP level and disease severity and prognosis in patients with early traumatic craniocerebral injury

ObjectiveTo investigate the relationship between early plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP) level and disease severity and prognosis in patients with traumatic craniocerebral injury.MethodsA retrospective research method was used to select 100 patients with traumatic craniocerebral injury as observation group.The plasma NT-proBNP level was recorded at 2, 12 and 24 hours of the onset, and the change was analyzed.According to Glasgow coma scale(GCS) score of patients at admission, patients with traumatic craniocerebral injury were divided into mild group, middle group and severe group.The plasma NT-proBNP level of the three groups was compared at indicated times, and the correlation between plasma NT-proBNP level and disease severity was explored.At 30 d after the onset, the patients with traumatic craniocerebral injury were divided into poor prognosis group and good prognosis group according to the Glasgow outcome scale(GOS) score, and the plasma NT-proBNP level of patients with different prognosis was compared.ResultsAt 2, 12 and 24 hours, there were significant differences in plasma NT-proBNP levels among the three groups, the mild group was lower than the other two groups, and the middle group was lower than the severe group(P < 0.01).There were significant differences in plasma NT-proBNP levels at 2, 12 and 24 hours of onset in the three groups(P < 0.01).The levels at 12 and 24 hours of onset in the mild group were significantly higher than those at 2 hours of onset(P < 0.01), the levels at 24 hours of onset in the middle group were significantly higher than those at 2 and 12 hours of onset(P < 0.01), the levels at 12 and 24 hours of onset in the severe group were significantly higher than those at 2 hours of onset(P < 0.01), and the levels at 24 hours of onset were significantly higher than those at 12 hours of onset(P < 0.01).At 2, 12 and 24 hours of onset, the NT-proBNP level in the good prognosis group was significantly lower than that in the poor prognosis group(P < 0.01).There were significant differences in NT-proBNP levels between the two groups at different times of onset(P < 0.01).At 12 and 24 hours of onset, both groups were higher than 2 hours of onset(P < 0.01), and the 24 hours of onset in the good prognosis group was higher than 12 hours of onset(P < 0.01).Plasma NT-proBNP was significantly negatively correlated with GCS and GOS scores(P < 0.01).ConclusionsThe level of plasma NT-proBNP in patients with traumatic craniocerebral injury is significantly increased in the early stage, and its expression level is negatively correlated with GCS and GOS score.The above-mentioned scores can be used to predict the changes of the disease in clinical practice.