| Abstract: | The aim of this study was to evaluate air and surface contaminations, and internalcontamination of healthcare workers during open-abdomen HIPEC using oxaliplatin. Platinum(Pt) was measured in urine of exposed workers and in multiple air and surface samples.Three successive HIPEC procedures were investigated in each of the two hospitalsparticipating in the study. Analysis of air samples did not detect any oxaliplatincontamination. Heavy contamination of the operating table, the floor at the surgeon’sfeet, and the surgeon’s overshoes were observed. Hand contamination was observed insurgeons using double gloves for intra-abdominal chemotherapy administration, but not inthose using three sets of gloves. Pt was not detected in urine samples obtained afterHIPEC (<5 ng/L). The main risk of HIPEC is related to direct or indirect skin exposureand can be prevented by correct use of adapted protective equipment. |
