99Tcm-MIBI SPECT/CT显像结合T/NT半定量分析对原发甲状旁腺腺瘤术前定位的价值

  目的  99Tcm-MIBI SPECT/CT显像结合T/NT半定量分析对原发甲状旁腺腺瘤术前定位的价值。  方法  回顾性分析我院术后诊断为原发甲状旁腺腺瘤81例患者的99Tcm--MIBI SPECT/CT显像及临床资料，结合T/NT半定量分析，探讨不同部位腺瘤的检出率。  结果  99Tcm-MIBI SPECT/CT断层显像、平面显像对腺瘤检出率分别为95.7%（67/70）、90%（63/70）；99Tcm-MIBI SPECT/ CT断层和平面显像腺瘤检出率差异无统计学意义（ χ2=1.723，P=0.189）。根据腺瘤的位置将腺瘤分为上侧和下侧。99Tcm-MIBI SPECT/CT断层显像、平面显像对上侧腺瘤检出率分别为92.8%（13/14）、85.7%（12/14），对下侧腺瘤检出率分别为100%（53/ 53）、100%（53/53）。99Tcm-MIBI SPECT/CT断层显像上下侧腺瘤检出率差异无统计学意义（ χ2=3.84，P=0.20），99Tcm-MIBI SPECT/CT平面显像下侧腺瘤检出率高于上侧（ χ2=7.80，P=0.04）。下侧腺瘤体积大于上侧（Z=-3.19，P=0.001），腺瘤体积和早期相T/NT比值及血清甲状旁腺激素具有弱相关性（r=0.475、0.329，P < 0.05）。  结论  通过对原发甲状旁腺瘤患者行术前99Tcm-MIBI SPECT/CT显像，并结合T/NT半定量分析，提高了不同部位腺瘤定位的准确度，能够为手术提供有价值的参考。 

Value of 99Tcm-MIBI SPECT/CT imaging combined with T/NT semi-quantitative analysis for pre-operative localization of primary parathyroid adenoma

  Objective  To investigate the value of 99Tcm-MIBI SPECT/CT imaging combined with T/NT semi-quantitative analysis in pre-operative of primary parathyroid adenoma.  Methods  The 99Tcm-MIBI SPECT/CT imaging and clinical data of 81 patients diagnosed with primary parathyroid adenoma were retrospectively analyze, to investigate the detection rate of parathyroid adenoma in different sites.  Results  The detection rate of 99Tcm-MIBI SPECT/CT tomography imaging, 99Tcm-MIBI SPECT/CT planar imaging were 95.7%(67/70) and 90%(63/70), respectively. There was no significant difference in detection rate between 99Tcm-MIBI SPECT/CT tomography imaging and planar imaging ( χ2=1.723, P=0.189). Adenomas are classified as superior and inferior according to their location, the detection rate of 99Tcm-MIBI SPECT/CT tomography imaging, 99Tcm-MIBI SPECT/CT planar imaging for superior adenomas were 92.8%(13/14)and 85.7%(12/14), and for inferior adenomas were 100%(53/53)and 100%(53/53), respectively. There was no significant difference in detection rate of adenomas between the upper and lower sides on 99Tcm-MIBI SPECT/CT tomography imaging ( χ2=3.84, P=0.20). The detection rate of inferior adenomas in 99Tcm-MIBI SPECT/CT planar imaging was higher on the lower side than on the upper side ( χ2=7.80, P=0.04). Adenoma volume on the inferior side was greater than on the superior side (Z=-3.19, P=0.001), and there was a weak correlation between adenoma volume and early phase T/NT ratio and serum parathyroid hormone (r=0.475, 0.329, P < 0.05).  Conclusion  By performing preoperation 99Tcm-MIBI SPECT/CT imaging in patients with primary parathyroid adenoma combined with T/NT semi-quantitative analysis, the accuracy of adenoma localization at different sites is improved and could provide a valuable reference for surgery.