| 非诺贝特制剂的研究进展 |
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| 引用本文： | 冯巧巧,张天佑,刘荣,宋凯,明奕,胡敬峰. 非诺贝特制剂的研究进展[J]. 药学研究, 2023, 42(3): 199-203 |
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| 作者姓名： | 冯巧巧 张天佑 刘荣 宋凯 明奕 胡敬峰 |
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| 作者单位： | 山东省食品药品审评查验中心，山东 济南 250014 |
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| 摘 要： | 非诺贝特属于贝特类降血酯药，是降低甘油三酯的首选药物之一，临床使用率高。由于非诺贝特难溶于水，不易于被吸收，导致生物利用度较低，影响药物疗效。为解决这一问题，不同类型的药物传递系统被应用与研究。本文综述非诺贝特制剂的研究进展，以期为其制剂的进一步开发提供思路。
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| 关 键 词： | 非诺贝特；生物利用度；微粉化；包合技术；微粒分散系 |
Research progress of Fenofibrate preparation |
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| FENG Qiaoqiao,ZHANG Tianyou,LIU Rong,SONG Kai,MING Yi,HU Jingfeng. Research progress of Fenofibrate preparation[J]. Journal of Pharmaceutical Research, 2023, 42(3): 199-203 |
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| Authors: | FENG Qiaoqiao ZHANG Tianyou LIU Rong SONG Kai MING Yi HU Jingfeng |
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| Abstract: | Fenofibrate belongs to the fibrate class of hypolipidemic drugs, and is one of the first-choice drugs for lowering triglycerides, with a high clinical usage rate. Since fenofibrate is insoluble in water and difficult to be absorbed, it leads to low bioavailability and reduced efficacy of the drug. To solve this problem, different types of formulations have emerged. This article reviews the research progress of fenofibrate formulations, in order to provide ideas for the further development of its formulations. |
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| Keywords: | Fenofibrate Bioavailability Micronizing Cyclodextrin inclusion Microparticle dispersion system |
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