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Targeting Mcl-1 inhibits survival and self-renewal of hepatocellular cancer stem-like cells
Affiliation:1. Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China;2. Open and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China;3. Zhengzhou Key Laboratory of Hepatobiliary and Pancreatic Diseases and Organ Transplantation, Zhengzhou, Henan, PR China;4. Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, Henan, PR China;5. Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China;1. Sorbonne Universités, UPMC Université Paris 06, INSERM, UMR_S 938, Saint-Antoine Research Center, 75012 Paris, France;2. AP–HP, Bicêtre Hospital, Biochemistry Laboratory, 94275 Le Kremlin-Bicêtre cedex, France;3. CNRS, UMR8161, Institut de Biologie de Lille, Université de Lille, Institut Pasteur de Lille, IFR 142, 59021 Lille cedex, France;4. Cliniques Universitaires Saint-Luc, 1200 Woluwe-Saint-Lambert, Belgium;5. De Duve Institute, Université catholique de Louvain, 1200 Brussels, Belgium;6. Institute of Cardiometabolism and Nutrition (ICAN), 75013 Paris, France;7. AP–HP, Pitié-Salpêtrière hospital, Unité Médicale de Transplantation Hépatique, 75013 Paris, France;1. Université Paris Descartes, Hepatology Department, Cochin Hospital, AP–HP, UPMC, 75014 Paris, France;2. Université Paris Descartes, Hepatology Department, Cochin Hospital, AP–HP, Inserm U1223, UMS-20, Center for Translational Science, Institut Pasteur, 75014 Paris, France;1. Department of Respiratory and Critical Care Medicine, Wuxi Branch of Ruijin Hospital, Wuxi, Jiangsu, China;2. Department of Cardiology and Hematology&Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China;1. Department of Gastroenterology, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon;2. Department of Medical Oncology, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon;3. Department of General Surgery, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon;1. Department of Gastroenterology, Jiangsu Taizhou People''s Hospital, Taizhou, PR China;2. Department of Paediatrics, Jiangsu Taizhou People''s Hospital, Taizhou, PR China;3. Department of Gastroenterology, Huai’an First People''s Hospital of Nanjing Medical University, Huai''an, PR China;4. Department of Gastroenterology, The Drum Tower Hospital of Nanjing University Medical School, Nanjing, PR China
Abstract:
Keywords:Hepatocellular carcinoma  Cancer stem-like cells  Mcl-1  Mcl-1 inhibitor
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