FABP4在胃腺癌患者血清中的表达及其临床意义

目的:探讨脂肪型脂肪酸结合蛋白4（FABP4）在胃腺癌患者血清中的表达及临床意义。方法:选取本院诊断及治疗的37例胃腺癌患者作为研究组，并选取健康体检人员74例作为对照组。采用酶联免疫吸附试验（ELISA）检测两组人群血清中FABP4的表达。分析血清中FABP4的表达与胃腺癌患者临床病理参数的关系，以及FABP4表达在诊断和预测胃腺癌预后中的作用。结果:胃腺癌患者血清中的FABP4相对表达量明显低于健康对照组（P<0.05）。肿瘤直径≤3 cm患者FABP4表达水平高于肿瘤直径＞3 cm患者（P<0.05）。TNM Ⅲ＋Ⅳ期患者血清FABP4水平显著低于Ⅰ＋Ⅱ期患者（P<0.05）。淋巴结转移阳性的患者血清FABP4水平低于淋巴结转移阴性患者（P<0.05）。FABP4诊断胃腺癌ROC曲线下面积（AUC）为0.703（P=0.001），灵敏度和特异度分别为73.0％和62.2％，界值为16.21；FABP4诊断胃腺癌淋巴结转移的ROC曲线下面积（AUC）为0.738（P=0.014），灵敏度和特异度分别为95.0％和52.9％，界值为16.37。结论:FABP4在胃腺癌患者血清中低表达，并且低表达FABP4与胃腺癌患者不良预后密切相关，可作为胃腺癌的新型生物标志物和诊断靶标。

Expression of FABP4 in serum of gastric adenocarcinoma patients and its clinical significance

Objective:To investigate the expression and clinical significance of fatty acid binding protein 4 (FABP4) in serum of patients with gastric adenocarcinoma.Methods:37 patients with gastric adenocarcinoma diagnosed and treated in our hospital were selected as the study group,and 74 healthy persons were selected as the control group.The expression of FABP4 in serum of the two groups was detected by enzyme-linked immunosorbent assay(ELISA).The relationship between serum FABP4 expression and clinicopathological parameters of patients with gastric adenocarcinoma was analyzed.The role of FABP4 expression in diagnosis and prognosis of gastric adenocarcinoma was analyzed.Results:The relative expression of FABP4 in the serum of patients with gastric adenocarcinoma was significantly lower than that of healthy controls(P<0.05).The expression level of FABP4 was higher in patients with tumor diameter≤3 cm than in patients with tumor diameter>3 cm(P<0.05).The serum FABP4 level was significantly lower in patients with TNM stage III+IV than in patients with stage I+II(P<0.05).The serum FABP4 level was lower in patients with positive lymph node metastasis than in patients with negative lymph node metastasis (P<0.05).The area under the ROC curve (AUC) of FABP4 for the diagnosis of gastric adenocarcinoma was 0.703 (P=0.001),with a sensitivity and specificity of 73.0% and 62.2%,respectively,and a cut-off value of 16.21.The ROC curve of FABP4 for the diagnosis of gastric adenocarcinoma with lymph node metastasis was 0.738(P=0.014),with a sensitivity and specificity of 95.0% and 52.9%,respectively,and a cut-off value of 16.37.Conclusion:FABP4 has a low expression in serum of gastric adenocarcinoma patients,and low expression of FABP4 is closely related to poor prognosis of gastric adenocarcinoma patients,which can be used as a new biomarker and diagnostic target of gastric adenocarcinoma.