伴与不伴躯体化症状青少年抑郁障碍病人白细胞介素水平研究

目的：检测青少年抑郁障碍病人血清白细胞介素(IL)水平，并分析其与躯体化症状的相关性。方法：选择2020年12月至2021年12月在合肥市第四人民医院治疗的13～18岁的青少年抑郁障碍病人93例，根据是否伴功能性躯体化症状(functional somatic symptoms, FSS),分为伴FSS组(40例)与不伴FSS组(53例)。同时选取32名正常青少年人群作为对照组。采用汉密尔顿抑郁量表(HAMD)、儿童躯体化量表(CSI)对疾病抑郁障碍现状进行评估。采用酶联免疫吸附试验法检测被试儿童血清IL-13及IL-12/23p40因子水平。结果：伴FSS青少年抑郁组IL-13因子水平显著高于不伴FSS组和对照组(P<0.05),不伴FSS组与对照组间差异无统计学意义(P>0.05);伴FSS组IL-12/23p40因子水平显著高于不伴FSS组(P<0.05),两者与对照组差异均无统计学意义(P>0.05)。IL-13水平与CSI总分及分因子分均呈正相关关系(r=0.360、0.286、0.366、0.310、0.336,P<0.01);IL-12/23...

Interleukin level in adolescent depressive disorders with and without somatic symptoms

ObjectiveTo analyze the serum interleukin level in patients with adolescent depression disorders, and analyze its correlation with somatic symptoms.MethodsA total of 93 patients with adolescent depression disorders treated in the Hefei Fourth People's Hospital from December 2020 to December 2021 were selected and divided into functional somatic symptoms (FSS) group (n=40) and non-FSS group (n=53) according to whether they were accompanied by FSS.At the same time, thirty-two volunteers were selected as the control group.The Hamilton depression rating scale (HAMD) and childhood somatization inventory (CSI) were used to evaluate the severity of disease.The enzyme-linked immunosorbent assay was applied to detect the levels of serum IL-13 and serum IL-12/23p40.ResultsThe level of IL-13 in FSS group was significantly higher than that of the non-FSS group and control group (P < 0.05), and there was no statistically significant difference between the non-FSS group and control group (P>0.05).The level of IL-12/23p40 in the FSS group significantly higher than that in the non-FSS group (P < 0.05), while both had no significant difference with control group (P>0.05).The level of IL-13 and IL-12/23p40 were positively correlated with CSI total score and its sub-factor scores (IL-13:r=0.360, 0.286, 0.366, 0.310, 0.336, P < 0.01;IL-12/23p40:r=0.333, 0.360, 0.275, 0.280, 0.313, P < 0.01).ConclusionsThe level of serum IL-13 in adolescent depression patients with somatic symptoms is abnormal, and it has a positive correlation patients with somatic symptoms.