New lignans and cytotoxic constituents from Wikstroemia lanceolata |
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Authors: | Lin Ru-Wei Tsai Ian-Lih Duh Chang-Yih Lee Kuo-Hsiung Chen Ih-Sheng |
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Institution: | Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan, Republic of China. |
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Abstract: | Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known sesquiterpenoid, 1alpha,7alpha,10alpha H-guaia-4,11-dien-3-one ( 24) were revised by 2D NMR techniques. Among the isolates, three compounds, (+)-hinokinin ( 6), 2,6-dimethoxy- p-benzoquinone ( 17), and 1alpha,7alpha,10alpha H-guaia-4,11-dien-3-one ( 24) exhibited effective cytotoxicities (ED50 values < 4.0 microg mL-1) against P-388 and HT-29 tumor cell lines. |
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