以尿崩症为首发表现的肺癌伴垂体转移六例临床分析

目的通过对以尿崩症为首发表现的肺癌垂体转移患者的临床资料分析,总结其临床特点,提高对尿崩症和垂体转移性肿瘤的认识和诊治水平。方法回顾性分析6例肺癌伴有垂体转移患者的临床和随诊资料,分析和探讨肺癌垂体转移的临床特点、诊断和治疗。结果6例患者平均年龄57·5岁。除垂体转移以外,还有其他多个部位转移。转移病灶多累及垂体后叶和垂体柄,常以尿崩症为首发表现和就诊原因,鞍区MRI可以出现特征性改变。伴有不同程度的垂体前叶功能减退。结论肺癌是引起垂体转移肿瘤的常见原因之一,以转移到垂体后叶多见。对于中老年新出现的中枢性尿崩症,应该重视系统性疾病的影响,寻找可能的原发肿瘤。

Lung cancer with metastasis to pituitary gland

Objective To improve the diagnostic accuracy of lung cancer with metastasis to pituitary gland. Methods The clinical data of 6 cases with lung cancer metastatic to pituitary gland were reviewed retrospectively and the features of clinical manifestations and sella MRI image analyzed. Results((1) The patients) had an average of 57.5 years of age. (2)Most of them had 2 additional metastatic sites other than pituitary gland. (3) Posterior lobe is mostly effected and the most common symptom is diabetes insipidus. The image of sella MRI had some special characteristics. (4) Pituitary anterior lobe function is often impaired in some degree. Conclusions Lung cancer is one of the commonest primary tumor with metastasis to pituitary gland and thorough exploration for primary cancer should be carried out in elderly patients with new onset of diabetes insipidus.