Interleukin-8 (IL-8) in synovial fluid of rheumatoid and nonrheumatoid joint effusions |
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Authors: | C. A. Verburgh M. H. L. Hart L. A. Aarden Dr. A. J. G. Swaak |
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Affiliation: | (1) Department of Internal Medicine, Zuiderziekenhuis, Rotterdam;(2) Department of Autoimmune Diseases, Central Laboratory of the Red Cross Blood Transfusion Service, Amsterdam;(3) Dept of Rheumatology, The Dr Daniel den Hoed Clinic, Groene Hilledijk 301, NL-3075 EA Rotterdam, The Netherlands |
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Abstract: | Summary IL-8 was measured in knee joint synovial fluid of 60 patients with rheumatoid arthritis, 8 with gout, 6 with osteoarthritis and 4 with meniscus lesions. IL-8 could be demonstrated in most SF samples. The highest levels were observed in rheumatoid joint effusions, yet mean levels were not significantly different between the different subgroups (mean±SE; RA 1537±3049 pg/ml, gout 570±952 pg/ml, OA/ML 178±188 pg/ml). In RA patients, IL-8 levels could not be related to various serological, clinical or radiological parameters. However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, 2-microglobulin and glucose. These observations suggest that next to the laboratory parameters IL-8 will be a parameter of the activity of the local inflammatory process. The results also demonstrate that IL-8 is not a disease-specific marker of joint inflammation. |
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Keywords: | Interleukin-8 IL-8 Synovial Fluid IL-8 |
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