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| 缺血预处理对局灶性脑缺血再灌注大鼠顶叶皮层bFGF表达的影响 | |
| 引用本文： | 安平,赵晓春,王玉勤,薛一雪.缺血预处理对局灶性脑缺血再灌注大鼠顶叶皮层bFGF表达的影响[J].解剖科学进展,2009,15(2):188-191. |
| 作者姓名： | 安平 赵晓春 王玉勤 薛一雪 |
| 作者单位： | 1. 中国医科大学,基础医学院,神经生物学教研室,辽宁,沈阳,110001 2. 中国医科大学,附属盛京医院麻醉科,辽宁,沈阳,110003 3. 辽宁中医学院,职业技术学院,生理学教研室,辽宁,沈阳,110101 |
| 基金项目： | 国家自然科学基金，辽宁省高等学校科研项目计划，辽宁省自然科学基金，沈阳市科学技术计划项目 |
| 摘 要： | 目的研究脑缺血预处理对大鼠局灶性脑缺血再灌注损伤及脑顶叶皮层碱性成纤维细胞生长因子(bFGF)表达的影响。方法线栓法阻塞32只大鼠大脑中动脉15min作为预处理,3天后线栓法制备大鼠大脑中动脉缺血模型,缺血2h再灌注24h后,缺血再灌注组32只。观察神经功能缺损程度、脑梗死体积、脑含水量、bFGF表达的变化。结果与对照组相比,脑缺血预处理组神经功能缺损评分明显降低(P<0.01),TTC染色显示脑梗死体积明显减小(P<0.01),缺血侧的脑水肿程度明显减轻(P<0.01),免疫组化和Westernblot检测表明脑顶叶皮层缺血周围组织bFGF表达水平明显升高(P<0.01),阳性细胞以神经元和胶质细胞为主。结论预先给予短暂性脑缺血预处理可对脑缺血再灌注损伤起保护作用,bFGF过表达可能是其机制之一。 |
| 关 键 词： | 脑缺血预处理 脑缺血再灌注 碱性成纤维细胞生长因子 大鼠 |
Effect of Ischemic Preconditioning on Expression of bFGF in Parietal Lobe of Focal Cerebral Ischemia-Reperfusion Rats |
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| AN Ping,ZHAO Xiao-chun,WANG Yu-qin,XUE Yi-xue.Effect of Ischemic Preconditioning on Expression of bFGF in Parietal Lobe of Focal Cerebral Ischemia-Reperfusion Rats[J].Progress of Anatomical Sciences,2009,15(2):188-191. | |
| Authors: | AN Ping ZHAO Xiao-chun WANG Yu-qin XUE Yi-xue |
| Institution: | 1.Department of Neurobiology;College of Basic Medical Sciences;ChinaMedical University;Liaoning Shenyang 110001;2.Department of Anaesthesiology;Shengjing Hospital;China Medical University;Liaoning Shenyang 110003;3.Department of Physiology;Vocational Technology College;Liaoning Chinese Traditional Medicine University;Liaoning Shenyang l1010l China |
| Abstract: | Objective To investigate the effect of ischemic preconditioning on the brain damage and expression of basic fibroblast growth factor(bFGF)in focal cerebral ischemia-reperfusion rats.Methods Cerebral ischemic preconditioning for 15min was given by middle cerebral artery ccclusion(MCAO)and 3d later MCAO was occluded for 2h and reperfused for 24h by intraluminal suture in 32 rats.Ischemia-reperfusion model was made as control in 32 rats.The neurological deficit,infarct volume and brain water content were evalu... |
| Keywords: | cerebral ischemic preconditioning cerebral ischemia-reperfusion bFGF rat |
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