| BNIP3基因及其与肿瘤的关系 |
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| 引用本文： | 谢晋予,郑长黎. BNIP3基因及其与肿瘤的关系[J]. 国际病理科学与临床杂志, 2006, 26(4): 6-301 |
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| 作者姓名： | 谢晋予 郑长黎 |
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| 作者单位： | 中南大学湘雅医学院病理学系,长沙,410078;中南大学湘雅医学院病理学系,长沙,410078 |
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| 摘 要： | BNIP3是bcl-2家族中BH3-only亚家族的成员，具有BH3结构域和跨膜区，属于促凋亡蛋白。BNIP3通过促进线粒体通透性转运孔开放和线粒体的损伤诱导凋亡，其表达受缺氧和其他因素的影响。近年研究发现BNIP3的表达异常和许多肿瘤的进展及耐药性有关。
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| 关 键 词： | BNIP3 凋亡 肿瘤 |
| 文章编号： | 1673-2588(2006)04-0298-04 |
| 收稿时间： | 2006-05-18 |
| 修稿时间： | 2006-05-18 |
BNIP3 gene and its relationship with tumor |
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| XIE Jin-yu,ZHENG Chang-li. BNIP3 gene and its relationship with tumor[J]. Journal of International Pathology and Clinical Medicine, 2006, 26(4): 6-301 |
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| Authors: | XIE Jin-yu ZHENG Chang-li |
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| Affiliation: | Department of Pathology, Xiangya Medical School, Central South University, Changsha 410013, China |
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| Abstract: | BNIP3,a member of BH3-only subfamily of bcl-2 superfamily,which has a BH3 domain and a trans-membrane domain,belongs to pro-apoptotic proteins.BNIP3 mediates apoptosis through mitochondrial permeability transport pore opening and mitochondrial dysfunction.The expression of BNIP3 is regulated by hypoxia and other factors.Studies have shown that abnormal expression of BNIP3 is correlated with the progression and drug-resistance of many tumors in recent years. |
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| Keywords: | BNIP3 apoptosis tumor |
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