前列地尔治疗糖尿病周围神经病变临床观察

目的观察并评价前列地尔治疗糖尿病周围神经病变（DPN）的临床疗效。方法纳入我院2009年2月~2010年2月住院部治疗的84例2型糖尿病患者,将患者随机分为A、B两组,各42例,分别采用前列地尔注射液和甲钴胺治疗,疗程均为2周。结果 A组患者的显效人数为37例,有效人数为3例,有效率为95.2%。A组患者的治疗效果显著好（P〈0.05）。两组患者的神经传导速度、空腹血糖（FPG）、餐后2 h血糖（2hPG）、糖化血红蛋白（HbA1c）差异均无统计学意义。结论采用前列地尔治疗糖尿病周围神经病变,可有效控制临床症状,增加神经传导速度,延缓病情发展,适合于临床上推广使用。

Clinical observation of diabetic peripheral neuropathy treated with Alprostadil

Objective To observe and evaluate the therapeutic effect of Alprostadil on diabetic peripheral neuropathy(DPN).Methods 84 cases of type 2 diabetic from February 2009 to February 2010 in our hospital were brought into study,the patients were randomly divided into A,B groups of 42 patients in each group using Alprostadil injection and Mecobalamin.The course of treatment was 2 weeks.Results The markedly number in A group was 37 cases,and effective number was 3 cases,so the effective rate was 95.2%.The A group of patients had a significant better treatment effect(P < 0.05).Nerve conduction velocity,fasting plasma glucose(FPG),2 hours postprandial plasma glucose(2hPG),glycosylated hemoglobin(HbA1c) were no significant difference between the two groups of patients.Conclusion The use of Alprostadil in treating diabetic peripheral neuropathy can effectively control the clinical symptoms,increase in nerve conduction velocity,delaying disease progression,which was confirmed to be suitable for clinical use.