米非司酮对子宫内膜异位症患者卵巢功能及血清糖链抗原125、人附睾蛋白4、糖链抗原199、炎性因子的影响观察

目的研究分析米非司酮对子宫内膜异位症患者卵巢功能及血清糖链抗原125（CA125）、人附睾蛋白4（HE4）、糖链抗原199（CA199）、炎性因子的影响。方法将2009年5月～2011年6月于本院进行治疗的80例子宫内膜异位症患者随机分为对照组和观察组,每组各40例,对照组采用丹那唑进行治疗,观察组采用米非司酮进行治疗,后将两组患者治疗前及治疗后3个月、6个月的卵巢功能及血清CA125、HE4、CA199、炎性因子进行比较。结果观察组治疗后3个月、6个月的卵巢功能检测项目血清CA125、HE4、CA199、炎性因子改善幅度均大于对照组,卵巢功能检测项目波动幅度则小于对照组,差异均有统计学意义（均P〈0.05）。结论米非司酮对子宫内膜异位症患者卵巢功能及血清CA125、HE4、CA199、炎性因子的影响较明显,对于疾病的治疗发挥着明显的作用。

Observation on the influence of Mifepristone for ovarian function,serum CA125,HE4,CA199 and inflammatory factors of patients with endometriosis

Objective To study and analyze the influence of Mifepristone for ovarian function,serum CA125,HE4,CA199 and inflammatory factors of patients with endometriosis.Methods 80 patients with endometriosis in our hospital from May 2009 to June 2011 were randomly divided into control group and observation group,with 40 cases in each group,the control group were treated with Danazol,the observation group were treated with Mifepristone,then the detection items of ovarian function,serum CA125,HE4,CA199 and inflammatory factors of two groups before and after the treatment at third and sixth month were compared.Results The improvement range of serum CA125,HE4,CA199 and inflammatory factors of observation group after the treatment at third and sixth month were all bigger than those of control group,detection items of ovarian function were smaller than those of control group,there were significant differences(all P < 0.05).Conclusion The influence of mifepristone for ovarian function,serum CA125,HE4,CA199 and inflammatory factors of patients with endometriosis is obvious,and it plays an active role in the treatment of disease.